Figure 1
From: Co-incidental increase in gene copy number of ERBB2 and LRIG1 in breast cancer
Increased copy number of LRIG1 and ERBB2 in human breast cancer in the same patient. Interphase nuclei from a breast cancer tumour were analysed by FISH. (a) A specific LRIG1 probe (red) showed increased LRIG1 copy number (five copies) whereas a specific centromere probe (CEP3) (green) showed normal chromosome 3 copy number (two copies). (b) A specific ERBB2 probe (red) showed amplification of the ERBB2 gene whereas a specific centromere probe (CEP17; green) showed three copies of chromosomes 17.