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Table 5 Clinicopathological comparison of serum biomarkers in breast cancer

From: The multiplex bead array approach to identifying serum biomarkers associated with breast cancer

Clinicopathological Concentration of biomarkers factors (mean ± SD) P value
T stage T1 to 2 (n = 85) T3 to 4 (n = 13)  
   A1AT (ng/ml)    4059.69 ± 6175.49    550.85 ± 712.09 0.001
   EGF (ng/ml)    265.71 ± 200.59    452.23 ± 221.82 0.017
   ApoH (μg/ml)    122.83 ± 30.97    144.18 ± 31.13 0.023
N stage N0 (n = 32) N1 to 3 (n = 66)  
   sVCAM-1 (ng/ml)    672.13 ± 109.22    755.17 ± 188.23 0.007
   Transthyretin (ng/ml)    160.62 ± 55.99    185.54 ± 58.18 0.047
M stage M0 (n = 90) M1 (n = 8)  
   proApoA1 (μg/ml)    27.38 ± 9.28    19.63 ± 13.41 0.032
ER expression Negative (n = 52) Positive (n = 44)  
   A2M (μg/ml)    66.73 ± 23.27    82.51 ± 31.51 0.006
   Vitronectin (ng/ml)    5458.08 ± 3224.21    4126.95 ± 1508.43 0.012
   Transthyretin (ng/ml)    187.61 ± 57.12    162.24 ± 51.31 0.025
   HMWK (ng/ml)    16767.50 ± 12263.40    22483.41 ± 14115.87 0.035
   PAI-1 (ng/ml)    20.22 ± 7.06    17.51 ± 5.68 0.043
PR expression Negative (n = 34) Positive (n = 62)  
   A2M (μg/ml)    65.59 ± 19.03    78.56 ± 31.52 0.031
   CA19-9 (U/ml)    27.16 ± 19.19    78.89 ± 187.35 0.035
c-erbB2 expression Negative (n = 42) Positive (n = 53)  
   sVCAM-1 (ng/ml)    770.21 ± 197.73    696.91 ± 143.80 0.047
   SAA (ng/ml)    2427.74 ± 250.48    5813.77 ± 11884.32 0.048
  1. A1AT = alpha-1 antitrypsin; A2M = alpha-2 macroglobulin; Apo = apolipoprotein; CA = cancer antigen; EGF = epidermal growth factor; ER = oestrogen receptor; HMWK = high-molecular-weight kininogen; PAI = plasminogen activator inhibitor; PR = progesterone receptor; ProApo = proapolipoprotein; SAA = serum amyloid A; SD = standard deviation; sVCAM = soluble vascular cell adhesion molecule.