Skip to main content

Table 5 Clinicopathological comparison of serum biomarkers in breast cancer

From: The multiplex bead array approach to identifying serum biomarkers associated with breast cancer

Clinicopathological Concentration of biomarkers factors (mean ± SD)

P value

T stage

T1 to 2 (n = 85)

T3 to 4 (n = 13)

 

   A1AT (ng/ml)

   4059.69 ± 6175.49

   550.85 ± 712.09

0.001

   EGF (ng/ml)

   265.71 ± 200.59

   452.23 ± 221.82

0.017

   ApoH (μg/ml)

   122.83 ± 30.97

   144.18 ± 31.13

0.023

N stage

N0 (n = 32)

N1 to 3 (n = 66)

 

   sVCAM-1 (ng/ml)

   672.13 ± 109.22

   755.17 ± 188.23

0.007

   Transthyretin (ng/ml)

   160.62 ± 55.99

   185.54 ± 58.18

0.047

M stage

M0 (n = 90)

M1 (n = 8)

 

   proApoA1 (μg/ml)

   27.38 ± 9.28

   19.63 ± 13.41

0.032

ER expression

Negative (n = 52)

Positive (n = 44)

 

   A2M (μg/ml)

   66.73 ± 23.27

   82.51 ± 31.51

0.006

   Vitronectin (ng/ml)

   5458.08 ± 3224.21

   4126.95 ± 1508.43

0.012

   Transthyretin (ng/ml)

   187.61 ± 57.12

   162.24 ± 51.31

0.025

   HMWK (ng/ml)

   16767.50 ± 12263.40

   22483.41 ± 14115.87

0.035

   PAI-1 (ng/ml)

   20.22 ± 7.06

   17.51 ± 5.68

0.043

PR expression

Negative (n = 34)

Positive (n = 62)

 

   A2M (μg/ml)

   65.59 ± 19.03

   78.56 ± 31.52

0.031

   CA19-9 (U/ml)

   27.16 ± 19.19

   78.89 ± 187.35

0.035

c-erbB2 expression

Negative (n = 42)

Positive (n = 53)

 

   sVCAM-1 (ng/ml)

   770.21 ± 197.73

   696.91 ± 143.80

0.047

   SAA (ng/ml)

   2427.74 ± 250.48

   5813.77 ± 11884.32

0.048

  1. A1AT = alpha-1 antitrypsin; A2M = alpha-2 macroglobulin; Apo = apolipoprotein; CA = cancer antigen; EGF = epidermal growth factor; ER = oestrogen receptor; HMWK = high-molecular-weight kininogen; PAI = plasminogen activator inhibitor; PR = progesterone receptor; ProApo = proapolipoprotein; SAA = serum amyloid A; SD = standard deviation; sVCAM = soluble vascular cell adhesion molecule.