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Table 4 Comparison of sensitivity of combinatorial markers vs. single marker

From: The multiplex bead array approach to identifying serum biomarkers associated with breast cancer

   Stage I to II Stage III to IV Total cases
Classification method Sensitivity (%) Sensitivity (%) Sensitivity (%)
Algorithm RF 86.3(44/51) 93.6(44/47) 89.8
  SVM 90.2(46/51) 93.6(44/47) 91.8
  LDA 82.4(42/51) 85.1(40/47) 83.7
Single marker CA15-3* 0 (0/49) 6.4 (3/47) 3.1 (3/96)
  TPA* 23.1 (9/39) 29.0 (11/38) 26.0 (20/77)
  1. *Cut-off levels of CA15-3 and TPA were 27 U/ml and 95 U/L, respectively.
  2. CA = cancer antigen; LDA = linear discriminant analysis; RF = random forests; SVM = support vector machine; TPA = tissue polypeptide antigen.