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Table 4 Comparison of sensitivity of combinatorial markers vs. single marker

From: The multiplex bead array approach to identifying serum biomarkers associated with breast cancer

  

Stage I to II

Stage III to IV

Total cases

Classification method

Sensitivity (%)

Sensitivity (%)

Sensitivity (%)

Algorithm

RF

86.3(44/51)

93.6(44/47)

89.8

 

SVM

90.2(46/51)

93.6(44/47)

91.8

 

LDA

82.4(42/51)

85.1(40/47)

83.7

Single marker

CA15-3*

0 (0/49)

6.4 (3/47)

3.1 (3/96)

 

TPA*

23.1 (9/39)

29.0 (11/38)

26.0 (20/77)

  1. *Cut-off levels of CA15-3 and TPA were 27 U/ml and 95 U/L, respectively.
  2. CA = cancer antigen; LDA = linear discriminant analysis; RF = random forests; SVM = support vector machine; TPA = tissue polypeptide antigen.