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Table 3 Diagnostic performance of three classification algorithms using combinatorial markers

From: The multiplex bead array approach to identifying serum biomarkers associated with breast cancer

Algorithm Marker combination Accuracy (%) Sensitivity
(%)
Specificity
(%)
   Train Validation Train Validation Train Validation
RF EGF, sCD40L, HMWK, ApoA1,
PAI-1, DD, VDBP, VN
91.8 93.8 89.8 92.8 93.7 94.7
SVM EGF, sCD40L, HMWK, ApoA1,
PAI-1, DD, VDBP, VN
91.5 88.4 89.5 87.5 93.4 89.3
LDA EGF, sCD40L, HMWK, ApoA1, PAI-1, VDBP 87.6 87.4 84.8 88.4 90.4 86.1
  1. Apo = apolipoprotein; DD = D-dimer; EGF = epidermal growth factor; HMWK = high-molecular-weight kininogen; LDA = linear discriminant analysis; PAI-1 = plasminogen activator inhibitor-1; RF = random forests; sCD40L = soluble CD-40 ligand; SVM = support vector machine; VDBP = vitamin-D binding protein.