The multiplex bead array approach to identifying serum biomarkers associated with breast cancer

Breast Cancer Research

Table 3 Diagnostic performance of three classification algorithms using combinatorial markers

Algorithm	Marker combination	Accuracy (%)		Sensitivity (%)		Specificity (%)
		Train	Validation	Train	Validation	Train	Validation
RF	EGF, sCD40L, HMWK, ApoA1, PAI-1, DD, VDBP, VN	91.8	93.8	89.8	92.8	93.7	94.7
SVM	EGF, sCD40L, HMWK, ApoA1, PAI-1, DD, VDBP, VN	91.5	88.4	89.5	87.5	93.4	89.3
LDA	EGF, sCD40L, HMWK, ApoA1, PAI-1, VDBP	87.6	87.4	84.8	88.4	90.4	86.1

Apo = apolipoprotein; DD = D-dimer; EGF = epidermal growth factor; HMWK = high-molecular-weight kininogen; LDA = linear discriminant analysis; PAI-1 = plasminogen activator inhibitor-1; RF = random forests; sCD40L = soluble CD-40 ligand; SVM = support vector machine; VDBP = vitamin-D binding protein.

ISSN: 1465-542X