Skip to main content

Advertisement

Table 2 Summary of differentially expressed serum markers between breast cancer and control subjects

From: The multiplex bead array approach to identifying serum biomarkers associated with breast cancer

Marker Breast cancer
(Mean ± SD)
Normal
(Mean ± SD)
P valuea AUC
EGF (pg/ml) 325.14 ± 208.39 76.67 ± 71.42   
sCD40L (pg/ml) 11226.31 ± 71363.00 32.17 ± 30.35 < 0.001 0.85
HMWK (ug/ml) 19.65 ± 13.49 33.98 ± 15.15 < 0.001 0.76
ApoA1 (ng/ml) 224.36 ± 94.02 322.70 ± 136.80 < 0.001 0.72
sVCAM-1 (ng/ml) 728.05 ± 170.55 832.57 ± 162.23 < 0.001 0.69
PAI-1 (ng/ml) 18.97 ± 6.51 23.38 ± 9.25 < 0.001 0.65
ProApoA1 (ng/ml) 26.74 ± 9823.61 22.14 ± 8.21 < 0.001 0.65
VDBP (ng/ml) 173.65 ± 36.15 191.63 ± 43.57 < 0.001 0.65
VN (ng/ml) 4848.98 ± 2626.57 5546.35 ± 2168.00 0.001 0.64
D-dimer (ng/ml) 1249.58 ± 259.30 539.70 ± 417.99 0.0340 0.59
A1AT (ng/ml) 3594.23 ± 5875.33 3143.05 ± 16616.57 0.808 0.51
CRP (ng/ml) 5154.88 ± 39551.30 2860.52 ± 16501.80 0.818 0.51
AFP (ng/ml) 0.81 ± 0.49 0.76 ± 0.53 0.376 0.54
CEA (ng/ml) 12.36 ± 8.75 10.24 ± 5.11 0.144 0.56
PSA (ng/ml) 0.02 ± 0.05 0.02 ± 0.1 0.750 0.51
CA125 (U/ml) 16.76 ± 71.52 4.91 ± 5.71 0.465 0.53
CA19-9 (U/ml) 60.17 ± 151.07 25.02 ± 20.67 0.016 0.60
B2M (ng/ml) 692.36 ± 166.13 720.68 ± 162.14 0.125 0.56
A2M (ng/ml) 74.00 ± 28.05 85.03 ± 34.28 0.010 0.61
Adiponectin (ng/ml) 12802.04 ± 10393.99 14358.12 ± 6563.28 0.014 0.60
MPO (pg/ml) 146459.9 ± 142930.01 112079.27 ± 100310.31 0.233 0.55
sICAM-1 (ng/ml) 162.31 ± 43.77 173.87 ± 57.84 0.171 0.56
IL-1β (pg/ml) 4.06 ± 11.12 2.74 ± 4.2 0.790 0.51
IL-1Rα (pg/ml) 269.47 ± 361.27 155.37 ± 207.52 0.008 0.61
IL-6 (pg/ml) 36.66 ± 94.93 33.27 ± 75.37 0.720 0.51
IL-8 (pg/ml) 450.89 ± 2970.97 24.24 ± 45.59 0.424 0.53
MCP-1 (pg/ml) 273.38 ± 312.79 280.57 ± 103.93 0.015 0.60
MIP-1α (pg/ml) 76.44 ± 225.17 56.39 ± 88.25 0.224 0.55
ApoA4 (ng/ml) 10382.14 ± 3924.34 10742.81 ± 3755.76 0.544 0.53
TTR (ng/ml) 177.40 ± 58.38 198.27 ± 65.85 0.029 0.59
Hp (ng/ml) 1080.38 ± 662.48 921.74 ± 448.23 0.197 0.55
SAA (ng/ml) 4261.8 ± 9028.56 2872.43 ± 5133.39 0.155 0.56
Hg (ng/ml) 249.95 ± 100.58 82 ± 44.23 < 0.001 0.66
CB (ng/ml) 943.79 ± 110.01 1081.19 ± 847.39 0.003 0.62
ApoH (ng/ml) 125.67 ± 131.69 128.54 ± 31.32 0.520 0.53
  1. aSpecific false discovery rate at a 1% level.
  2. A1AT = alpha-1 antitrypsin; A2M = alpha-2 macroglobulin; AFP = alpha-fetoprotein; Apo = apolipoprotein; AUC = area under the curve; B2M = beta-2 macroglobulin; CA = cancer antigen; CB = cathepsin B; CEA = carcinoembryonic antigen; CRP = C-reactive protein; EGF = epidermal growth factor; Hg = haemoglobin; HMWK = high-molecular-weight kininogen; Hp = haptoglobin; IL = interleukin; MCP = monocyte chemotactic protein; MIP = monocyte inflammatory protein; MPO = myeloperoxidase; PAI = plasminogen activator inhibitor; ProApo = proapolipoprotein; PSA = prostate specific antigen; SAA = serum amyloid A; sCD40L = soluble CD-40 ligand; SD = standard deviation; ICAM = intercellular adhesion molecule; sVCAM = soluble vascular cell adhesion molecule; TTR = transthyretin;VDBP = vitamin-D binding protein; VN = vitronectin.