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Table 1 List of biomarkers in 35-plex panel

From: The multiplex bead array approach to identifying serum biomarkers associated with breast cancer

Marker list

Oncofetal protein

Acute phase protein

Alpha-fetoprotein (AFP)

Alpha-1-antitrypin (A1AT)a

Carcinoembryonic antigen (CEA)

Alpha-2 macroglobulin (A2M)c

Cancer antigen 125 (CA125)c

C-reactive protein (CRP)b

Cancer antigen 19-9 (CA19-9)c

D-dimer (DD)c

Prostate-specific antigen (PSA)c

Haptoglobin α (Hp)a

Cytokine

Serum amyloid A (SAA)b

Interleukin-1β (IL-1β)c

Transthyretin (TTR)a

Interleukin-1 receptor α (IL-Rα)c

Coagulation/thrombosis

Interleukin-6 (IL-6)c

Haemoglobin (Hg)b

Interleukin-8 (IL-8)c

High-molecular-weight kininogen (HMWK)c

Monocyte chemotactic protein-1

(MCP-1)c

Plasminogen activator inhibitor-1

(PAI-1)c

Monocyte inflammatory protein-1α (MIP-1α)c

Metabolism

Immune/inflammation

Apolipoprotein A1 (ApoA1)c

Soluble CD40 ligand (sCD40L)c

Pro-apolipoprotein A1 (proApoA1)a

β2-microglobulin (β 2M)b

Apolipoprotein A4 (ApoA4)a

Myeloperoxidase (MPO)c

Apolipoprotein H (ApoH)b

Factor/hormone

Carrier

Epidermal growth factor (EGF)c

Vitamin D-binding protein (VDBP)b

Adiponectinc

Enzyme

Adhesion

Cathepsin B (CB)c

Vitronectin (VN)c

 

Soluble vascular cell adhesion molecule-1 (sVCAM-1)c

 

Soluble intercellular cell adhesion molecule-1 (sICAM-1)c

 
  1. aMarkers were discovered through two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) using the serum of breast cancer patients. bMarkers were discovered through surface-enhanced laser desorption/ionisation time-of-flight (SELDI-TOF) mass spectrometry. cMarkers were selected using literature search.