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Table 1 Results of IHC of c-Met and FISH of LSI D7S486/CEP7 applied to lobular and ductal carcinomas

From: FISH and immunohistochemical status of the hepatocyte growth factor receptor (c-Met) in 184 invasive breast tumors

 

IHC c-Met

FISH MET

FISH + IHC

 

Negative

Positive

Negative

Polysomy

PE + P

Carcinoma type

     

   Lobular

57 (76%)

18 (24%)

61 (81%)

15 (19%)

5 (7%)

   Ductal (DIC)

42 (52%)

38 (48%)

60 (75%)

20 (25%)

13 (16%)

DIC type

     

   ER+/PR+

31 (68%)

15 (32%)

39 (85%)

7 (15%)

3 (6%)

   ER+/PR-

11 (32%)

23 (68%)

21 (62%)

13 (38%)

10 (29%)

  1. DIC, ductal infiltrating carcinoma; PE, positive expression; ER, estrogen receptor; FISH, fluorescent in situ hybridization; IHC, immunohistochemistry; P, polysomy; PR, progesterone receptor. In bold we remark the positive FISH and IHQ results for DIC as well as for ER+/PR- tumors