T-cell metagene predicts a favorable prognosis in estrogen receptor-negative and HER2-positive breast cancers

Breast Cancer Research

Table 2 Multivariate Cox regression of lymphocyte-specific kinase metagene and standard parameters among estrogen receptor-negative tumors

Parameter	Stratification	n ₁ ^a	n ₂ ^a	P value^b	Hazard ratio	95% confidence interval
Lymphocyte-specific kinase metagene	Low vs. high	60	64	0.017	2.16	1.15 to 4.03
Lymph node status	LNN vs. N1	89	35	0.059	1.84	0.98 to 3.47
Age	>50 years vs. ≤ 50 years	71	53	0.91	0.97	0.53 to 1.78
Pathological grading	Poor vs. well/intermediate	83	41	0.97	1.01	0.53 to 1.95
Tumor size	>2 cm vs. ≤ 2 cm	76	48	0.078	1.85	0.93 to 3.66
Human epidermal growth factor receptor 2 status	Positive vs. negative	45	79	0.78	1.09	0.58 to 2.05

^aComplete information on all parameters was available for 124 estrogen receptor-negative samples. ^bSignificant values presented in bold.

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