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Table 2 Methylated CpG islands not associated with known genes

From: Methylation of homeobox genes is a frequent and early epigenetic event in breast cancer

Target number

Symbol

CpG island locationa

Average ratiob

Count

1

CGI 1:42

Chr1: 38714506 to 38714991

6.27

4

2

CGI 6:60

Chr6: 106535804 to 106536465

4.69

4

3

CGI 2:112

Chr2: 239419845 to 239420943

4.22

4

4

CGI 4:34

Chr4: 174658599 to 174659018

2.94

4

5*

CGI 7:48

Chr7: 35460738 to 35461227

17.26

3

6

CGI 8:121

Chr8: 100054909 to 100056159

16.81

3

7

CGI 10:46b

Chr10: 119484483 to 119484981

15.44

3

8

CGI 17:16

Chr17: 44182434 to 44182640

13.96

3

9

CGI 7:351

Chr7: 129205522 to 129209745

11.56

3

10

CGI 6:19

Chr6: 27755772 to 27755984

10.16

3

11

CGI 8:31

Chr8: 81968510 to 81968882

8.45

3

12

CGI 22:48

Chr22: 44655029 to 44655728

7.98

3

13

CGI 2:77

Chr2: 176639821 to 176640909

7.91

3

14

CGI 5:47

Chr5: 176039674 to 176040127

7.78

3

15

CGI 7:29

Chr7: 129210233 to 129210591

7.60

3

16

CGI 3:47

Chr3: 134875805 to 134876344

6.58

3

17*

CGI 4:35

Chr4: 24699204 to 24699608

6.22

3

18

CGI 6:18

Chr6: 27571155 to 27571358

6.18

3

19

CGI 7:277

Chr7: 154857318 to 154860615

5.91

3

20

CGI 10:46

Chr10: 102409137 to 102409658

5.84

3

21

CGI 4:21

Chr4: 174657922 to 174658134

5.53

3

22

CGI X:92

Chrx: 136459742 to 136460985

4.81

3

23

CGI 22:18

Chr22: 47762399 to 47762664

4.15

3

24

CGI 1:130

Chr1: 199774402 to 199775940

3.77

3

25

CGI 5:26

Chr5: 3379328 to 3379645

3.42

3

26

CGI 5:87

Chr5: 134853297 to 134854395

3.16

3

27

CGI 8:72

Chr8: 1100465 to 1101480

2.35

3

  1. aFor uncharacterized gene targets, CpG island location was assigned instead of gene location. bAverage of the log2 ratios assigned to positive peaks across the six DCIS. Targets with methylated peaks within the CpG island in at least three out of six DCIS samples were considered significant. *Unknown CpG islands verified by combined bisulfite restriction analysis assays or bisulfite sequencing.