Figure 3

Changes in volume of human breast cancer xenograft tumors in mice after paclitaxel administration. Cells were inoculated subcutaneously into the mammary fat pads of female nude mice, and 10 days later paclitaxel (circles) or vehicle (squares) was administered daily by intraperitoneal injection for 5 days (arrows). (a) MDA-MB-468 cells. (b) MDA-MB-231 cells. (c) T47D cells. (d) MCF-7 cells. Tumor dimension was measured daily for 12 days after the first dose. Each point represents the mean (bar, standard deviation) of seven independent measurements of tumor size. Percentage of relative tumor growth calculated as the mean tumor volume on each day divided by the mean volume at the time of the first paclitaxel or vehicle administration.