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Table 4 Protein expression levels in relation to clinicopathological properties

From: Determination of HER2 phosphorylation at tyrosine 1221/1222 improves prediction of poor survival for breast cancer patients with hormone receptor-positive tumors

  Tumor grade Tumor size Nodal status Recurrence Death
  1 2 3 <2 cm 2 to 5 cm >5 cm 0 1 to 3 ≥4 No Yes No Yes
HER2              
   Negative 61 96 49 78 149 19 22 137 87 169 77 137 109
   Positive 1 7 14 7 12 3 0 12 10 10 12 9 13
   P value 0.0003 (+) 0.506 0.335 0.034 (+) 0.190
pHER1              
   Negative 50 82 49 62 136 19 16 125 76 150 67 121 196
   Positive 10 20 14 20 24 3 6 21 20 25 22 22 25
   P value 0.731 0.188 0.180 0.042 (+) 0.333
pHER2              
   Negative 43 57 24 49 92 14 12 88 55 105 50 91 64
   Weak 17 26 22 20 47 4 8 42 21 55 16 41 30
   Strong 1 19 17 12 22 4 2 16 20 16 22 12 26
   P value 0.0001 (+) 0.811 0.189 0.001 (+) 0.009 (+)
pHER3              
   Negative 50 88 50 69 134 18 20 123 78 153 68 122 99
   Positive 10 15 13 12 25 3 2 21 17 22 18 20 20
   P value 0.582 1.000 0.607 0.099 0.606
HER4              
   Low 10 32 27 24 49 12 7 41 37 38 47 36 49
   High 51 67 35 56 109 10 13 105 57 133 42 104 71
   P value 0.004 (-) 0.088 0.174 <0.0001 (-) 0.012 (-)
pErk              
   Negative 20 45 35 32 72 9 12 57 44 76 37 63 50
   Moderate 13 25 11 18 40 3 4 33 24 42 19 32 29
   Strong 22 32 16 27 45 10 5 50 27 52 30 42 40
   P value 0.261 0.514 0.593 0.798 0.817
pAkt              
   Negative 10 29 20 20 46 4 8 33 29 48 22 42 28
   Moderate 30 34 26 38 59 9 9 54 43 64 42 58 48
   Strong 20 39 16 23 54 8 5 55 25 60 25 42 43
   P value 0.103 0.588 0.195 0.287 0.419
  1. Fisher's exact test was used to obtain the P values. (+) and (-), positive and negative correlations. Bold data represent significant values.