Predicted probabilities and classification of the BRCA1 unclassified variants from this study. Box-plots for the BRCA1 unclassified variants (UVs) along with the control groups of deleterious and neutral variants. Dotted cutoff lines, probability from the corresponding model that minimizes the receiver operating characteristic distance. The median of each UV and of the control groups (mutations and neutral variants) are presented below. In addition, the number of families above the cutoff point and the total number of families (n/N) is presented along with the probability of having at least one correct prediction (Prob.) and the probability if all families of the UV under consideration were on the cutoff point (threshold). Finally, the classification (C) as a deleterious variant (D) or not known (N) is also presented. The UVs that have been reported to be either deleterious or neutral in the literature are displayed in bold.