Predicted probabilities of the BRCA1 control populations. Plot showing the predicted probabilities of the control populations – deleterious (mutations) and neutral variants (polymorphisms) – in BRCA1 using the logistic regression model obtained for BRCA1. Dotted cutoff lines, probability from the BRCA1 model that minimizes the receiver operating characteristic (ROC) distance. For each genetic variant, the number of families above the cutoff point and the total number of families (n/N) is presented on the right side along with the probability of having at least one correct prediction (Prob.) and the probability if all families of the genetic variant under consideration were on the cutoff point (threshold). Finally, the classification (C) as a deleterious variant (D) or not known (N) is also presented. Sequence nomenclature: NCBI reference sequence U14680.1 (BRCA1), numbering starting at the A of the ATG translation initiation codon.