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Table 5 Top 50 genes differentially expressed in tumor-associated stroma

From: Gene expression profiling of the tumor microenvironment during breast cancer progression

Probe set DCIS IDC Gene description
Hs.179729.0.S1_3p_a_at 6.5 7.0 COL10A1 – collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia)
Hs.28792.0.S1_3p_at 5.9 6.0 NA
4876385_3p_at 4.9 6.3 COL11A1 – collagen, type XI, alpha 1
g7019348_3p_at 4.9 5.7 GREM1 – gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
Hs.179729.1.S1_3p_a_at 4.8 5.5 COL10A1 – collagen, type X, alpha 1(Schmid metaphyseal chondrodysplasia)
Hs.297939.3.S1_3p_at 4.6 5.1 FNDC1 – fibronectin type III domain containing 1
37892_3p_at 4.1 5.6 COL11A1 – collagen, type XI, alpha 1
Hs.41271.0.S1_3p_at 4.7 4.9 COL8A1 – collagen, type VIII, alpha 1
g4502938_3p_s_at 3.8 5.4 COL11A1 – collagen, type XI, alpha 1
g186414_3p_a_at 4.5 4.4 INHBA – inhibin, beta A
g8393842_3p_at 4.4 4.4 NOX4 – NADPH oxidase 4
Hs.288467.0.S1_3p_at 3.8 4.8 LRRC15 – leucine rich repeat containing 15
Hs.105700.0.S1_3p_a_at 4.1 4.2 SFRP4 – secreted frizzled-related protein 4
g4481752_3p_at 3.6 4.4 GJB2 – gap junction protein, beta 2, 26 kDa
g8923132_3p_at 3.6 4.3 ASPN – asporin
Hs.287820.2.A1_3p_s_at 3.8 4.1 FN1 – fibronectin 1
g8400733_3p_a_at 3.5 3.9 SFRP4 – secreted frizzled-related protein 4
g10863087_3p_a_at 3.4 3.9 GREM1 – gremlin 1, cysteine knot superfamily, homolog (Xenopus laevis)
g5174662_3p_at 3.4 3.4 S100P – S100 calcium binding protein P
Hs.283713.0.A1_3p_at 3.2 3.5 CTHRC1 – collagen triple helix repeat containing 1
g4502844_3p_at 3.1 3.5 CILP – cartilage intermediate layer protein, nucleotide pyrophosphohydrolase
Hs.76722.2.S1_3p_at 2.8 3.7 -
Hs.70823.0.S3_3p_at 3.3 3.2 SULF1 – sulfatase 1
g4505186_3p_at 3.3 3.0 CXCL9 – chemokine (C-X-C motif) ligand 9
Hs.101302.0.S2_3p_s_at 2.2 3.9 COL12A1 – collagen, type XII, alpha 1
g11415037_3p_at -3.2 -3.0 SLC22A3 – solute carrier family 22 (extraneuronal monoamine transporter), member 3
Hs.325823.0.A1_3p_at -2.7 -3.5 CD36 – CD36 molecule (thrombospondin receptor)
g4557418_3p_at -2.7 -3.6 CD36 – CD36 molecule (thrombospondin receptor)
g4557544_3p_a_at -2.9 -3.5 EDN3 – endothelin 3
Hs2.147313.1.S1_3p_s_at -2.9 -3.5 CD300LG – CD300 molecule-like family member g
Hs.106283.4.S1_3p_at -3.0 -3.4 KLHL13 – kelch-like 13 (Drosophila)
g8400731_3p_a_at -2.6 -4.0 SFRP1 – secreted frizzled-related protein 1
Hs.250692.0.S4_3p_at -3.0 -3.7 HLF – hepatic leukemia factor
g4826977_3p_at -3.3 -3.5 RELN – reelin
Hs.76325.1.A1_3p_x_at -3.0 -3.9 IGJ – immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
Hs.76325.1.A1_3p_at -3.1 -4.0 IGJ – immunoglobulin J polypeptide, linker protein for immunoglobulin alpha and mu polypeptides
g10835124_3p_a_at -4.0 -3.1 DCX – doublecortex; lissencephaly, X-linked (doublecortin)
g7657105_3p_at -3.2 -4.0 GABRP – gamma-aminobutyric acid A receptor, pi
g4506328_3p_at -3.4 -3.9 PTPRZ1 – protein tyrosine phosphatase, receptor-type, Z polypeptide 1
g4758377_3p_at -3.9 -3.4 FIGF – c-fos induced growth factor (vascular endothelial growth factor D)
g12707575_3p_at -3.3 -4.1 OXTR – oxytocin receptor
g13518036_3p_a_at -2.5 -4.9 MATN2 – matrilin 2
g4559274_3p_a_at -3.9 -3.6 ELF5 – E74-like factor 5 (ets domain transcription factor)
Hs.10587.0.S1_3p_at -2.5 -5.1 DMN – desmuslin
Hs.49696.0.A1_3p_at -3.7 -4.0 SCARA5 – scavenger receptor class A, member 5 (putative)
g4557578_3p_at -3.4 -4.4 FABP4 – fatty acid binding protein 4, adipocyte
g13186315_3p_a_at -3.5 -4.3 CAPN6 – calpain 6
g11991655_3p_at -3.2 -5.3 C2orf40 – chromosome 2 open reading frame 40
g562105_3p_a_at -4.9 -4.5 DLK1 – delta-like 1 homolog (Drosophila)
g6005949_3p_at -5.0 -4.8 WIF1 – WNT inhibitory factor 1
  1. Ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) data presented as log2(fold changes) relative to normal stroma.