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Table 4 Top 50 genes differentially expressed in tumor epithelium

From: Gene expression profiling of the tumor microenvironment during breast cancer progression

Probe set

DICS

IDC

Gene description

g5174662_3p_at

5.3

4.0

S100P – S100 calcium binding protein P

g11993936_3p_s_at

4.5

3.4

CYB561 – cytochrome b-561

g7415720_3p_a_at

4.0

3.0

SCD – stearoyl-CoA desaturase (delta-9-desaturase)

Hs.75319.0.S3_3p_at

3.0

3.8

RRM2 – ribonucleotide reductase M2 polypeptide

Hs.106552.0.S3_3p_s_at

4.2

2.3

CNTNAP2 – contactin associated protein-like 2

g12803628_3p_at

3.7

2.6

HIST1H1C – histone cluster 1, H1c

g5031780_3p_at

4.0

2.3

IFI27 – interferon, alpha-inducible protein 27

Hs.180779.1.S1_3p_at

3.1

3.0

HIST1H2BD – histone cluster 1, H2bd

Hs.184572.0.S2_3p_at

2.7

3.3

CDC2 – cell division cycle 2, G1 to S and G2 to M

Hs.223025.0.S2_3p_a_at

2.6

3.4

RAB31 – RAB31, member RAS oncogene family

g12804874_3p_a_at

2.8

3.1

RRM2 – ribonucleotide reductase M2 polypeptide

Hs.239884.0.S1_3p_x_at

3.5

2.4

HIST1H2BC – histone cluster 1, H2bc

g7661973_3p_at

2.7

3.1

MELK – maternal embryonic leucine zipper kinase

g13259549_3p_at

3.2

2.4

IFI6 – interferon, alpha-inducible protein 6

g4504584_3p_at

3.5

2.0

IFIT1 – interferon-induced protein with tetratricopeptide repeats 1

Hs.155956.0.S1_3p_at

2.6

2.8

NAT1 – N-acetyltransferase 1 (arylamine N-acetyltransferase)

Hs.152677.0.S1_3p_at

3.1

2.3

DHRS2 – dehydrogenase/reductase (SDR family) member 2

Hs.239884.0.S1_3p_at

3.3

2.1

HIST1H2BC – histone cluster 1, H2bc

g5803130_3p_a_at

2.2

3.2

RAB31 – RAB31, member RAS oncogene family

g13699814_3p_s_at

2.7

2.7

CYP2B6 – cytochrome P450, family 2, subfamily B, polypeptide 6

g9963780_3p_a_at

2.2

3.2

RAB31 – RAB31, member RAS oncogene family

Hs.72472.0.A1_3p_at

2.3

2.9

-

g13477106_3p_s_at

3.3

1.8

CEACAM6 – carcinoembryonic antigen-related cell adhesion molecule 6 (nonspecific cross-reacting antigen)

Hs.133342.0.S1_3p_x_at

2.9

2.2

GPC1 – glypican 1

Hs.325335.1.S1_3p_at

2.6

2.5

CAPN13 – calpain 13

Hs.34853.0.S2_3p_at

-3.5

-4.0

ID4 – inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

g3387766_3p_a_at

-3.9

-3.6

GPM6B – glycoprotein M6B

Hs.10587.0.S1_3p_at

-3.2

-4.3

DMN – desmuslin

Hs2.348883.1.S1_3p_s_at

-3.9

-3.6

FOXC1 – forkhead box C1

g4758521_3p_at

-4.9

-2.7

SPARCL1 – SPARC-like 1 (mast9, hevin)

g11037715_3p_x_at

-3.9

-3.7

ROPN1 – ropporin, rhophilin associated protein 1

g4504914_3p_at

-3.9

-3.8

KRT15 – keratin 15

Hs.82101.0.S3_3p_at

-3.7

-4.0

PHLDA1 – pleckstrin homology-like domain, family A, member 1

Hs.149356.0.S1_3p_at

-3.8

-3.9

LOC728264 – hypothetical protein LOC728264

g4506856_3p_s_at

-3.3

-4.6

CX3CL1 – chemokine (C-X3-C motif) ligand 1

g4506516_3p_at

-3.9

-4.1

RGS2 – regulator of G-protein signaling 2, 24 kDa

g7657105_3p_at

-4.2

-4.0

GABRP – gamma-aminobutyric acid (GABA) A receptor, pi

Hs.25956.0.S1_3p_at

-4.1

-4.4

SOSTDC1 – sclerostin domain containing 1

Hs.153961.2.S2_3p_at

-4.6

-3.9

BOC – Boc homolog (mouse)

g11991655_3p_at

-4.5

-4.2

C2orf40 – chromosome 2 open reading frame 40

Hs.288850.0.S1_3p_at

-4.1

-4.7

PHLDA1 – pleckstrin homology-like domain, family A, member 1

g7662650_3p_at

-5.1

-3.7

C13orf15 – chromosome 13 open reading frame 15

g4557694_3p_a_at

-4.5

-4.5

KIT – v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog

Hs.127428.2.S2_3p_a_at

-4.3

-4.9

HOXA9 – homeobox A9

g6005949_3p_at

-4.4

-4.8

WIF1 – WNT inhibitory factor 1

Hs.34853.0.S3_3p_at

-4.8

-4.5

ID4 – inhibitor of DNA binding 4, dominant negative helix-loop-helix protein

g4559274_3p_a_at

-4.1

-5.3

ELF5 – E74-like factor 5 (ets domain transcription factor)

g8400731_3p_a_at

-4.4

-5.2

SFRP1 – secreted frizzled-related protein 1

g5032314_3p_a_at

-4.9

-4.9

DMD – dystrophin (muscular dystrophy, Duchenne and Becker types)

g6005714_3p_at

-4.7

-5.6

SLC6A14 – solute carrier family 6 (amino acid transporter), member 14

  1. Ductal carcinoma in situ (DCIS) and invasive ductal carcinoma (IDC) data presented as log2(fold changes) relative to normal epithelium.