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Table 1 Survey of mouse tumours derived from hCAP18 overexpressing MJ1105 and its control.

From: Human antimicrobial protein hCAP18/LL-37 promotes a metastatic phenotype in breast cancer

Cell line Mouse Sacrificed day past inoculation Primary tumour size (mm) Metastases Lymph
nodes
Ascites with eGFP cells eGFP cells in spleen GFP cells in liver
MJ 1105-
hCAP18
h1 43 6 × 6 × 6      
  h2 71 10 × 8 × 8     + +
  h3 71 8 × 8 × 8   3    +
  h4 75 8 × 8 × 8 3 abdominal 2 +   
  h5 90 8 × 5 × 4   1    
MJ1105
eGFP
I1 43 10 × 10 × 10      
  I2 43 8 × 7 × 6      
  I3 90 7 × 10 × 6      
  I4 90 8 × 4 × 4   1    
  1. For statistical evaluation, each visible metastasis or node, or the presence of fluorescent cells in ascites/spleen or liver, are counted as one event each. Using the Mann-Whitney U-test, the median number of metastatic events between the groups is significant (p = 0.05). eGFP = enhanced green fluorescent protein.