Tamoxifen induces pleiotrophic changes in mammary stroma resulting in extracellular matrix that suppresses transformed phenotypes

Table 2 Fibrillar collagen content of mammary glands

Grade of collagen deposition^a	Control group	Tamoxifen group
Grade I	5 (23%)	0 (0%)
Grade II	12 (54%)	9 (38%)
Grade III	5 (23%)	15 (62%)

^aGrade I glands are at least 50% adipocyte-rich stroma and devoid of dense fibrillar collagen deposition. Grade II glands have moderate levels of dense fibrillar collagen or areas with mixed collagen densities and Grade III glands have at least 50% of glands filled with dense fibrillar collagen deposition.

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