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Table 1 Histoclinical correlations of breast cancers according to CD146 expression

From: CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines

Characteristic DNA microarray Tissue microarray
  CD146-rich (n = 113) P value* CD146+ (n = 45) P value*
Age
   < 45 years 36/74 NS 9/85 NS
   ≥ 45 years 59/115   36/549  
Pathological type
   Ductal 92/179 NS 36/472 NS
   Lobular 17/43   2/77  
   Tubular    1/40  
   Medullar    1/8  
   Mixed    2/25  
   Other    4/26  
Molecular subtype
   Basal 44/67 <0.0001   
   ERBB2 15/31    
   Luminal 32/93    
   Normal 16/21    
Scarff Bloom and Richardson grade
   I + II 26/77 <0.0001 18/463 <0.0001
   III 87/149   27/163  
Tumor size
   < 20 28/53 NS 17/281 NS
   ≥ 20 54/122   26/347  
Pathological axillary lymph node status
   Negative 52/90 NS   
   Positive 54/122    
Immunohistochemistry estrogen receptor status
   Negative 72/119 <0.0001 28/141 <0.0001
   Positive 41/108   13/460  
Immunohistochemistry progesterone receptor status
   Negative 83/137 <0.0001 35/208 <0.0001
   Positive 30/90   9/362  
Immunohistochemistry ERBB2 status
   Negative 83/169 NS 40/515 NS
   Positive 19/36   2/46  
Immunohistochemistry estrogen receptor/progesterone receptor/ERBB2 status
   Triple negative    25/76 <0.0001
   Other    13/425  
Immunohistochemistry p53 status
   Negative    14/330 0.0046
   Positive    15/124  
Immunohistochemistry Bcl2 status
   Negative    22/138 <0.0001
   Positive    18/388  
Immunohistochemistry CD44 status
   Negative    1/136 0.0225
   Positive    17/283  
Immunohistochemistry epithelial growth factor receptor status
   Negative    3/284 0.00011
   Positive    9/81  
Immunohistochemistry GATA3 status
   Negative    30/203 0.00032
   Positive    10/313  
Immunohistochemistry Moesin status
   Negative    4/339 <0.0001
   Positive    13/65  
Immunohistochemistry P-cadherin status
   Negative    1/199 0.00021
   Positive    14/173  
  1. *To assess differences in clinicopathologic features between the two groups of patients, Fisher's exact test was used for qualitative variables with discrete categories.