Skip to main content

Table 1 Histoclinical correlations of breast cancers according to CD146 expression

From: CD146 expression is associated with a poor prognosis in human breast tumors and with enhanced motility in breast cancer cell lines

Characteristic

DNA microarray

Tissue microarray

 

CD146-rich (n = 113)

P value*

CD146+ (n = 45)

P value*

Age

   < 45 years

36/74

NS

9/85

NS

   ≥ 45 years

59/115

 

36/549

 

Pathological type

   Ductal

92/179

NS

36/472

NS

   Lobular

17/43

 

2/77

 

   Tubular

  

1/40

 

   Medullar

  

1/8

 

   Mixed

  

2/25

 

   Other

  

4/26

 

Molecular subtype

   Basal

44/67

<0.0001

  

   ERBB2

15/31

   

   Luminal

32/93

   

   Normal

16/21

   

Scarff Bloom and Richardson grade

   I + II

26/77

<0.0001

18/463

<0.0001

   III

87/149

 

27/163

 

Tumor size

   < 20

28/53

NS

17/281

NS

   ≥ 20

54/122

 

26/347

 

Pathological axillary lymph node status

   Negative

52/90

NS

  

   Positive

54/122

   

Immunohistochemistry estrogen receptor status

   Negative

72/119

<0.0001

28/141

<0.0001

   Positive

41/108

 

13/460

 

Immunohistochemistry progesterone receptor status

   Negative

83/137

<0.0001

35/208

<0.0001

   Positive

30/90

 

9/362

 

Immunohistochemistry ERBB2 status

   Negative

83/169

NS

40/515

NS

   Positive

19/36

 

2/46

 

Immunohistochemistry estrogen receptor/progesterone receptor/ERBB2 status

   Triple negative

  

25/76

<0.0001

   Other

  

13/425

 

Immunohistochemistry p53 status

   Negative

  

14/330

0.0046

   Positive

  

15/124

 

Immunohistochemistry Bcl2 status

   Negative

  

22/138

<0.0001

   Positive

  

18/388

 

Immunohistochemistry CD44 status

   Negative

  

1/136

0.0225

   Positive

  

17/283

 

Immunohistochemistry epithelial growth factor receptor status

   Negative

  

3/284

0.00011

   Positive

  

9/81

 

Immunohistochemistry GATA3 status

   Negative

  

30/203

0.00032

   Positive

  

10/313

 

Immunohistochemistry Moesin status

   Negative

  

4/339

<0.0001

   Positive

  

13/65

 

Immunohistochemistry P-cadherin status

   Negative

  

1/199

0.00021

   Positive

  

14/173

 
  1. *To assess differences in clinicopathologic features between the two groups of patients, Fisher's exact test was used for qualitative variables with discrete categories.