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Table 3 Summary of most significant SNPs associated with survival independent of known prognostic factors using Cox proportional hazards analysis

From: The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer

Gene/SNP

Genotype

n

Events

Censored

Median survival (years)

Hazard ratio

95% CI

P value

MAP3K1/rs889312

AA

383

76

307

2.393

Reference

  
 

CA

361

48

313

2.577

0.624

0.435 to 0.897

0.011

 

CC

82

10

72

2.508

0.627

0.324 to 1.215

0.166

 

Dominant

443

58

385

2.564

0.625

0.443 to 0.881

0.007

Desert/rs13281615

AA

280

51

229

2.531

Reference

  
 

GA

375

49

326

2.517

0.749

0.504 to 1.113

0.153

 

GG

170

34

136

2.326

1.349

0.871 to 2.089

0.180

 

Recessive

170

34

136

2.326

1.569

1.060 to 2.323

0.024

MMP7/rs1943779

TT

429

85

344

2.431

Reference

  
 

CT

331

47

283

2.477

0.702

0.490 to 1.005

0.053

 

CC

67

3

54

2.847

0.217

0.069 to 0.689

0.009

 

Dominant

398

50

337

2.539

0.617

0.435 to 0.876

0.007

TOX3/rs1420542

AA

551

80

471

2.523

Reference

  
 

TA

223

47

176

2.487

1.601

1.114 to 2.300

0.011

 

TT

41

8

33

1.970

2.069

0.995 to 4.303

0.052

 

Dominant

264

55

209

2.407

1.654

1.170 to 2.339

0.004

  1. CI, confidence interval; SNP, single nucleotide polymorphism.