Skip to main content

Table 3 Summary of most significant SNPs associated with survival independent of known prognostic factors using Cox proportional hazards analysis

From: The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer

Gene/SNP Genotype n Events Censored Median survival (years) Hazard ratio 95% CI P value
MAP3K1/rs889312 AA 383 76 307 2.393 Reference   
  CA 361 48 313 2.577 0.624 0.435 to 0.897 0.011
  CC 82 10 72 2.508 0.627 0.324 to 1.215 0.166
  Dominant 443 58 385 2.564 0.625 0.443 to 0.881 0.007
Desert/rs13281615 AA 280 51 229 2.531 Reference   
  GA 375 49 326 2.517 0.749 0.504 to 1.113 0.153
  GG 170 34 136 2.326 1.349 0.871 to 2.089 0.180
  Recessive 170 34 136 2.326 1.569 1.060 to 2.323 0.024
MMP7/rs1943779 TT 429 85 344 2.431 Reference   
  CT 331 47 283 2.477 0.702 0.490 to 1.005 0.053
  CC 67 3 54 2.847 0.217 0.069 to 0.689 0.009
  Dominant 398 50 337 2.539 0.617 0.435 to 0.876 0.007
TOX3/rs1420542 AA 551 80 471 2.523 Reference   
  TA 223 47 176 2.487 1.601 1.114 to 2.300 0.011
  TT 41 8 33 1.970 2.069 0.995 to 4.303 0.052
  Dominant 264 55 209 2.407 1.654 1.170 to 2.339 0.004
  1. CI, confidence interval; SNP, single nucleotide polymorphism.