Skip to main content

Table 2 Risk of breast cancer comparing 899 POSH cases with 2,980 WTCCC controls

From: The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer

Gene SNP Risk allele Frequency Trend test Genotypic test P value
    Cases Controls OR (95% CI) P value  
TOX3 rs3803662 A 0.2905 0.2567 1.19 (1.05 to 1.33) 0.0054 0.0188
CASP8 rs12693932 T 0.4933 0.4552 1.17 (1.05 to 1.30) 0.0051 0.0144
ESR1 rs2228480 A 0.2007 0.2308 0.84 (0.73 to 0.95) 0.0064 0.0053
ADH1B rs1042026 C 0.3068 0.2803 1.13 (1.01 to 1.28) 0.0307 0.0975
ESR1 rs3798577 C 0.4983 0.4713 1.11 (1.00 to 1.24) 0.0441 0.1231
  1. CI, confidence interval; OR, odds ratio; POSH, Prospective study of Outcomes in Sporadic versus Hereditary breast cancer; SNP, single nucleotide polymorphism; WTCCC, Wellcome Trust Case Control Consortium.