Skip to main content

Table 2 Risk of breast cancer comparing 899 POSH cases with 2,980 WTCCC controls

From: The influence of genetic variation in 30 selected genes on the clinical characteristics of early onset breast cancer

Gene

SNP

Risk allele

Frequency

Trend test

Genotypic test P value

   

Cases

Controls

OR (95% CI)

P value

 

TOX3

rs3803662

A

0.2905

0.2567

1.19 (1.05 to 1.33)

0.0054

0.0188

CASP8

rs12693932

T

0.4933

0.4552

1.17 (1.05 to 1.30)

0.0051

0.0144

ESR1

rs2228480

A

0.2007

0.2308

0.84 (0.73 to 0.95)

0.0064

0.0053

ADH1B

rs1042026

C

0.3068

0.2803

1.13 (1.01 to 1.28)

0.0307

0.0975

ESR1

rs3798577

C

0.4983

0.4713

1.11 (1.00 to 1.24)

0.0441

0.1231

  1. CI, confidence interval; OR, odds ratio; POSH, Prospective study of Outcomes in Sporadic versus Hereditary breast cancer; SNP, single nucleotide polymorphism; WTCCC, Wellcome Trust Case Control Consortium.