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Table 6 Odds ratios (OR) and 95% confidence intervals (CI)a between LUM SNP rs2268578 and breast cancer risk, stratified by tumor estrogen receptor status among 1,641 Caucasian subjects (Mayo Clinic 2001 to 2005) and 9,030 Caucasian subjects (SEARCH study 1990 to 2005)b

From: Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies

  Estrogen receptor-positive Estrogen receptor-negative
Model Mayo Clinic sample SEARCH sample Pooled Mayo Clinic + SEARCH sample Mayo Clinic sample SEARCH sample Pooled Mayo Clinic + SEARCH sample
  Cases/controls OR (95% CI) Cases/controls OR (95% CI) OR (95% CI) Cases/controls OR (95% CI) Cases/controls OR (95% CI) OR (95% CI)
General           
   0 copy 340/661 1.0 (referent) 1,506/3,506 1.0 (referent) 1.0 (referent) 86/661 1.0 (referent) 344/3,506 1.0 (referent) 1.0 (referent)
   1 copy 125/167 1.5 (1.1 to 1.9) 431/980 1.0 (0.9 to 1.1) 1.1 (0.9 to 1.2) 20/167 0.9 (0.5 to 1.5) 107/980 1.0 (0.8 to 1.4) 1.0 (0.8 to 1.3)
   2 copies 17/13 2.5 (1.2 to 5.3) 47/62 1.6 (1.0 to 2.5) 1.9 (1.3 to 2.8) 3/13 1.7 (0.4 to 6.5) 5/62 0.8 (0.3 to 2.0) 1.0 (0.5 to 2.2)
P valuec   0.001   0.10 0.001   0.67   0.79 0.98
Ordinal   1.5 (1.2 to 1.9)   1.1 (0.9 to 1.2) 1.1 (1.0 to 1.3)   1.0 (0.7 to 1.6)   1.0 (0.8 to 1.3) 1.0 (0.8 to 1.2)
P trend   0.0003   0.29 0.01   0.89   0.93 0.86
  1. aMayo sample adjusted for age and region of residence (Minnesota, Iowa, Wisconsin, Illinois, North Dakota and South Dakota); SEARCH sample adjusted for age; pooled Mayo + SEARCH sample adjusted for age and study. b798 cases and 843 controls (Mayo Clinic sample), and 4,470 cases and 4,560 controls (SEARCH sample). Numbers do not total due to missing tumor status: 1,985 (44%) in SEARCH and 206 (26%) in Mayo Clinic sample. cTwo-degrees-of-freedom test.