| DCN rs3138165 | LUM rs2268578 | ||||||||
---|---|---|---|---|---|---|---|---|---|---|
Model | Mayo Clinic sample (MAF = 0.06) | SEARCH sample (MAF = 0.07) | Pooled Mayo Clinic + SEARCH sample | Mayo Clinic sample (MAF = 0.11) | SEARCH sample (MAF = 0.12) | Pooled Mayo Clinic + SEARCH sample | ||||
 | Cases/controls | OR (95% CI) | Cases/controls | OR (95% CI) | OR (95% CI) | Cases/controls | OR (95% CI) | Cases/controls | OR (95% CI) | OR (95% CI) |
General | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
   0 copy | 668/741 | 1.0 (referent) | 3,801/3,965 | 1.0 (referent) | 1.0 (referent) | 567/661 | 1.0 (referent) | 3,306/3,506 | 1.0 (referent) | 1.0 (referent) |
   1 copy | 123/98 | 1.4 (1.0 to 1.8) | 547/558 | 1.0 (0.9 to 1.2) | 1.1 (0.9 to 1.2) | 207/167 | 1.4 (1.1 to 1.8) | 972/980 | 1.1 (0.9 to 1.2) | 1.1 (1.0 to 1.2) |
   2 copies | 6/4 | 1.8 (0.5 to 6.3) | 19/20 | 0.8 (0.4 to 1.7) | 1.1 (0.6 to 2.1) | 23/13 | 2.2 (1.1 to 4.3) | 85/62 | 1.4 (1.0 to 2.1) | 1.6 (1.2 to 2.3) |
P valuec | Â | 0.08 | Â | 0.87 | 0.61 | Â | 0.002 | Â | 0.13 | 0.005 |
Ordinal | Â | 1.3 (1.0 to 1.8) | Â | 1.0 (0.9 to 1.1) | 1.1 (0.9 to 1.2) | Â | 1.4 (1.2 to 1.8) | Â | 1.1 (1.0 to 1.2) | 1.1 (1.0 to 1.2) |
P trend | Â | 0.03 | Â | 0.96 | 0.32 | Â | 0.0003 | Â | 0.10 | 0.004 |