| |
DCN rs3138165
|
LUM rs2268578
|
|---|
|
Model
|
Mayo Clinic sample (MAF = 0.06)
|
SEARCH sample (MAF = 0.07)
|
Pooled Mayo Clinic + SEARCH sample
|
Mayo Clinic sample (MAF = 0.11)
|
SEARCH sample (MAF = 0.12)
|
Pooled Mayo Clinic + SEARCH sample
|
|---|
| |
Cases/controls
|
OR (95% CI)
|
Cases/controls
|
OR (95% CI)
|
OR (95% CI)
|
Cases/controls
|
OR (95% CI)
|
Cases/controls
|
OR (95% CI)
|
OR (95% CI)
|
|---|
|
General
| | | | | | | | | | |
|
0 copy
|
668/741
|
1.0 (referent)
|
3,801/3,965
|
1.0 (referent)
|
1.0 (referent)
|
567/661
|
1.0 (referent)
|
3,306/3,506
|
1.0 (referent)
|
1.0 (referent)
|
|
1 copy
|
123/98
|
1.4 (1.0 to 1.8)
|
547/558
|
1.0 (0.9 to 1.2)
|
1.1 (0.9 to 1.2)
|
207/167
|
1.4 (1.1 to 1.8)
|
972/980
|
1.1 (0.9 to 1.2)
|
1.1 (1.0 to 1.2)
|
|
2 copies
|
6/4
|
1.8 (0.5 to 6.3)
|
19/20
|
0.8 (0.4 to 1.7)
|
1.1 (0.6 to 2.1)
|
23/13
|
2.2 (1.1 to 4.3)
|
85/62
|
1.4 (1.0 to 2.1)
|
1.6 (1.2 to 2.3)
|
|
P valuec
| |
0.08
| |
0.87
|
0.61
| |
0.002
| |
0.13
|
0.005
|
|
Ordinal
| |
1.3 (1.0 to 1.8)
| |
1.0 (0.9 to 1.1)
|
1.1 (0.9 to 1.2)
| |
1.4 (1.2 to 1.8)
| |
1.1 (1.0 to 1.2)
|
1.1 (1.0 to 1.2)
|
|
P trend
| |
0.03
| |
0.96
|
0.32
| |
0.0003
| |
0.10
|
0.004
|
- MAF, minor allele frequency. aMayo Clinic sample adjusted for age and region of residence (Minnesota, Iowa, Wisconsin, Illinois, North Dakota and South Dakota); SEARCH sample adjusted for age; pooled Mayo Clinic + SEARCH sample adjusted for age and study. b798 cases and 843 controls (Mayo Clinic sample), and 4,470 cases and 4,560 controls (SEARCH sample). cTwo-degrees-of-freedom test.
