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Table 5 Odds ratios (OR) and 95% confidence intervals (CI)a between polymorphisms in the decorin (DCN) and lumican (LUM) genes and breast cancer risk among 1,641 Caucasian subjects (Mayo Clinic 2001 to 2005) and 9,030 Caucasian subjects (SEARCH study 1990 2005)b

From: Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies

  DCN rs3138165 LUM rs2268578
Model Mayo Clinic sample (MAF = 0.06) SEARCH sample (MAF = 0.07) Pooled Mayo Clinic + SEARCH sample Mayo Clinic sample (MAF = 0.11) SEARCH sample (MAF = 0.12) Pooled Mayo Clinic + SEARCH sample
  Cases/controls OR (95% CI) Cases/controls OR (95% CI) OR (95% CI) Cases/controls OR (95% CI) Cases/controls OR (95% CI) OR (95% CI)
General           
   0 copy 668/741 1.0 (referent) 3,801/3,965 1.0 (referent) 1.0 (referent) 567/661 1.0 (referent) 3,306/3,506 1.0 (referent) 1.0 (referent)
   1 copy 123/98 1.4 (1.0 to 1.8) 547/558 1.0 (0.9 to 1.2) 1.1 (0.9 to 1.2) 207/167 1.4 (1.1 to 1.8) 972/980 1.1 (0.9 to 1.2) 1.1 (1.0 to 1.2)
   2 copies 6/4 1.8 (0.5 to 6.3) 19/20 0.8 (0.4 to 1.7) 1.1 (0.6 to 2.1) 23/13 2.2 (1.1 to 4.3) 85/62 1.4 (1.0 to 2.1) 1.6 (1.2 to 2.3)
P valuec   0.08   0.87 0.61   0.002   0.13 0.005
Ordinal   1.3 (1.0 to 1.8)   1.0 (0.9 to 1.1) 1.1 (0.9 to 1.2)   1.4 (1.2 to 1.8)   1.1 (1.0 to 1.2) 1.1 (1.0 to 1.2)
P trend   0.03   0.96 0.32   0.0003   0.10 0.004
  1. MAF, minor allele frequency. aMayo Clinic sample adjusted for age and region of residence (Minnesota, Iowa, Wisconsin, Illinois, North Dakota and South Dakota); SEARCH sample adjusted for age; pooled Mayo Clinic + SEARCH sample adjusted for age and study. b798 cases and 843 controls (Mayo Clinic sample), and 4,470 cases and 4,560 controls (SEARCH sample). cTwo-degrees-of-freedom test.