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Table 3 Odds ratios (OR) and 95% confidence intervals (CI)a between polymorphisms in the decorin (DCN) and lumican (LUM) genes and breast cancer risk among 1,641 Caucasian subjectsb, Mayo Clinic 2001 to 2005

From: Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies

Polymorphism/rsID MAF Homozygotes common allele (referent OR = 1) Heterozygotesc Homozygotes rare allelec Per allele P trend
   Cases Controls Cases Controls OR (95% CI) Cases Controls OR (95% CI) OR (95% CI)  
DCN            
   rs7441 0.06 675 744 119 95 1.3 (1.0 to 1.8) 4 4 1.2 (0.3 to 4.7) 1.3 (1.0 to 1.7) 0.05
   rs516115 0.26 397 470 336 316 1.2 (1.0 to 1.5) 65 57 1.3 (0.9 to 2.0) 1.2 (1.0 to 1.4) 0.03
   rs3138165 0.06 668 741 123 98 1.4 (1.0 to 1.8) 6 4 1.8 (0.5 to 6.3) 1.3 (1.0 to 1.8) 0.03
   rs741212 0.12 616 662 167 167 1.1 (0.8 to 1.4) 15 14 1.2 (0.6 to 2.5) 1.1 (0.9 to 1.3) 0.51
   rs10492230 0.16 557 589 216 231 1.0 (0.8 to 1.2) 25 23 1.2 (0.7 to 2.1) 1.0 (0.8 to 1.2) 0.88
LUM            
   rs1920790 0.12 594 653 188 180 1.1 (0.9 to 1.4) 16 10 1.8 (0.8 to 3.9) 1.2 (0.9 to 1.4) 0.13
   rs17714469 0.10 647 683 141 152 1.0 (0.7 to 1.2) 10 8 1.3 (0.5 to 3.3) 1.0 (0.8 to 1.3) 1.0
   rs10745553 0.15 559 613 214 212 1.1 (0.9 to 1.4) 24 17 1.6 (0.8 to 3.0) 1.1 (0.9 to 1.4) 0.14
   rs2268578 0.11 567 661 207 167 1.4 (1.1 to 1.8) 23 13 2.2 (1.1 to 4.3)d 1.4 (1.2 to 1.8) 0.0003
   rs10859110 0.22 418 517 331 283 1.4 (1.2 to 1.7) 49 43 1.4 (0.9 to 2.2)d 1.3 (1.1 to 1.5) 0.001
   rs17018765 0.06 673 744 121 95 1.4 (1.0 to 1.8) 4 4 1.2 (0.3 to 4.7) 1.3 (1.0 to 1.7) 0.04
  1. MAF, minor allele frequency. aAdjusted for age and region of residence (Minnesota, Iowa, Wisconsin, Illinois, North Dakota and South Dakota). b798 cases and 843 controls. cReferent (OR = 1) is homozygous common allele group. dTwo-degrees-of-freedom test, P = 0.002.