Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies

Table 3 Odds ratios (OR) and 95% confidence intervals (CI)^a between polymorphisms in the decorin (DCN) and lumican (LUM) genes and breast cancer risk among 1,641 Caucasian subjects^b, Mayo Clinic 2001 to 2005

Polymorphism/rsID	MAF	Homozygotes common allele (referent OR = 1)		Heterozygotes^c			Homozygotes rare allele^c			Per allele	P trend
		Cases	Controls	Cases	Controls	OR (95% CI)	Cases	Controls	OR (95% CI)	OR (95% CI)
DCN
rs7441	0.06	675	744	119	95	1.3 (1.0 to 1.8)	4	4	1.2 (0.3 to 4.7)	1.3 (1.0 to 1.7)	0.05
rs516115	0.26	397	470	336	316	1.2 (1.0 to 1.5)	65	57	1.3 (0.9 to 2.0)	1.2 (1.0 to 1.4)	0.03
rs3138165	0.06	668	741	123	98	1.4 (1.0 to 1.8)	6	4	1.8 (0.5 to 6.3)	1.3 (1.0 to 1.8)	0.03
rs741212	0.12	616	662	167	167	1.1 (0.8 to 1.4)	15	14	1.2 (0.6 to 2.5)	1.1 (0.9 to 1.3)	0.51
rs10492230	0.16	557	589	216	231	1.0 (0.8 to 1.2)	25	23	1.2 (0.7 to 2.1)	1.0 (0.8 to 1.2)	0.88
LUM
rs1920790	0.12	594	653	188	180	1.1 (0.9 to 1.4)	16	10	1.8 (0.8 to 3.9)	1.2 (0.9 to 1.4)	0.13
rs17714469	0.10	647	683	141	152	1.0 (0.7 to 1.2)	10	8	1.3 (0.5 to 3.3)	1.0 (0.8 to 1.3)	1.0
rs10745553	0.15	559	613	214	212	1.1 (0.9 to 1.4)	24	17	1.6 (0.8 to 3.0)	1.1 (0.9 to 1.4)	0.14
rs2268578	0.11	567	661	207	167	1.4 (1.1 to 1.8)	23	13	2.2 (1.1 to 4.3)^d	1.4 (1.2 to 1.8)	0.0003
rs10859110	0.22	418	517	331	283	1.4 (1.2 to 1.7)	49	43	1.4 (0.9 to 2.2)^d	1.3 (1.1 to 1.5)	0.001
rs17018765	0.06	673	744	121	95	1.4 (1.0 to 1.8)	4	4	1.2 (0.3 to 4.7)	1.3 (1.0 to 1.7)	0.04

MAF, minor allele frequency. ^aAdjusted for age and region of residence (Minnesota, Iowa, Wisconsin, Illinois, North Dakota and South Dakota). ^b798 cases and 843 controls. ^cReferent (OR = 1) is homozygous common allele group. ^dTwo-degrees-of-freedom test, P = 0.002.

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