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Table 1 Genetic polymorphisms in the decorin (DCN) and lumican (LUM) genes and minor allele frequencies (MAFs) among 843 Caucasian controls, Mayo Clinic 2001 to 2005

From: Genetic variation in stromal proteins decorin and lumican with breast cancer: investigations in two case-control studies

Gene Location rsID Polymorphic region Amino acid change MAF (controls)
DCN 12q21.33 rs7441 Ex8 G/A 3' UTR   0.06
   rs3138268 Ex7 G/A Met268Thr 0
   rs516115 IVS3 A/G   0.26
   rs3138165a IVS1 G/A 5' UTR   0.06
   rs2070985a IVS1 G/C 5' UTR   0.06
   rs741212 IVS1 A/G 5' UTR   0.12
   rs13312816a IVS1 A/T   0.06
   rs10492230 G/A 5' upstream   0.16
LUM 12q21.3–q22 rs1920790 A/C 3' downstream   0.12
   rs17714469 G/A 3' downstream   0.10
   rs10745553 IVS2 G/C   0.15
   rs2268578 IVS2 G/A   0.11
   rs10859110 IVS1 G/A   0.22
   rs17018765 A/G 5' upstream   0.06
  1. aLinkage disequilibrium r2 ≥ 0.98 for all pairwise combinations of these SNPs.
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Breast Cancer Research

ISSN: 1465-542X

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