Table 2 Features that may guide selection for treatment-focused genetic counselling and testing

Strong family history consistent with dominantly inherited breast/ovarian cancer

Two or more first- or second-degree relatives on one side of the family plus one or more of the following features on the same side of the family^a:

   Additional relatives with breast or ovarian cancer

   Breast cancer diagnosed before the age of 40 years

   Bilateral breast cancer

   Breast and ovarian cancer in the same woman

   Ashkenazi Jewish ancestry

   Breast cancer in a male relative

One or more first- or second-degree relatives with breast cancer at age 45 years or younger plus another first- or second-degree relative on the same side of the family with sarcoma (bone/soft tissue) at age 45 years or younger

Young age of onset^b especially in combination with:

At least one first-degree relative with breast or ovarian cancer; or

Bilateral breast cancer; or

Specific ethnic group with known founder mutations, for example, Ashkenazi Jewish ancestry; or

Presence of a triple negative breast tumours (ER, progesterone receptor and HER2 negative) or their subgroup of basal-cell like tumours