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Figure 3 | Breast Cancer Research

Figure 3

From: A comprehensive analysis of prognostic signatures reveals the high predictive capacity of the Proliferation, Immune response and RNA splicing modules in breast cancer

Figure 3

Classification and stratification of poor outcome for distant metastasis-free survival and breast cancer-specific survival. (a) Classification results of the nine gene signatures on the collection of 1,127 samples with distant metastasis-free survival (DMFS) (left panel) and breast cancer-specific survival (BCSS) (right panel) as the endpoints. In both panels, breast cancer samples are depicted in columns, and signatures in rows. Each cell colored according to the outcome of the signature in the corresponding row for the patient in the associated column: blue, poor outcome; yellow, good outcome. Top three lanes represent clinical parameters. HER2, HER2 status with red representing amplified cases and green nonamplified cases (as determined from gene expression); ER, estrogen receptor status with red representing ER-negative cases and green ER-positive cases as determined by gene expression; Meta or Death, DMFS or BCSS with events indicated in black. Represented signatures: HU, Intrinsic/UNC gene set [15]; IGS, Invasiveness Gene signature [16]; CIN70 and CIN25, Chromosomal Instability signatures [13]; GGI, Gene expression Grade Index [25]; T17 and T52, Molecular Prognostic Index signature [20]; CSR, Core Serum Response signature [14]; and Wang, the 76-gene signature [8]. For the subtyping based on the Intrinsic/UNC gene set, assignment to the Luminal B, Basal and HER2 subtypes was scored as poor outcome while assignment to the Luminal A and Normal types was scored as good outcome. Shaded regions highlight those patients classified as good outcome or poor outcome by all signatures. (b) Kaplan–Meier curves for the population of 1,127 samples stratified according to the number of times a sample is assigned to the poor outcome category with DMFS (left panel) and BCSS (right panel) as the endpoints. Graphs depict the curves for four subgroups: all good group (no poor outcome assignments; green), mainly good group (one to three poor outcome assignments; blue), mainly poor group (four to six poor outcome assignments; purple), and poor group (seven to nine poor outcome assignments; black).

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