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Figure 1 | Breast Cancer Research

Figure 1

From: Serial analysis of gene expression of lobular carcinoma in situ identifies down regulation of claudin 4 and overexpression of matrix metalloproteinase 9

Figure 1

Pathology of the index case. (a, b) Low power view showing terminal ductal lobular units distended by small discohesive cells, typical of lobular carcinoma in situ (LCIS). Note the prominent perilobular oedema and fibrosis. (c) Higher power view showing discohesive nature of LCIS cells and focal intracytoplasmic vacuoles (signet-ring cells). (d) E-cadherin protein is absent in the LCIS cells by immunohistochemistry, confirming the diagnosis. Note the intact labelling in residual duct epithelial cells, providing an internal control.

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Breast Cancer Research

ISSN: 1465-542X

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