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Table 8 Univariate and multivariate analysis of the six genes in relation to RFS among the 33 breast cancer samples from the independent cohort (Centre Léon Bérard, Lyon, France)

From: A candidate molecular signature associated with tamoxifen failure in primary breast cancer

Genes

Univariate (n = 33)

Multivariate (n = 33)

 

HR

95% CI

P a

HR

95% CI

P a

ESR1

0.12

0.04 to 0.36

<10-4

  

NS

FOS

0.20

0.08 to 0.51

<10-4

0.15

0.03 to 0.89

0.038

BCL2

0.08

0.02 to 0.24

<10-4

0.10

0.03 to 0.34

<10-4

SNCG

0.46

0.19 to 1.11

NS

NDb

ND

ND

IGFBP4

0.46

0.19 to 1.12

NS

ND

ND

ND

MET

1.38

0.60 to 3.21

NS

ND

ND

ND

  1. aP value was considered significant when P < 0.05. bND indicates 'not done'; multivariate analysis was done using the variables found to be significant in univariate analysis. CI, confidence interval; HR, hazard ratio; NS, not significant; RFS, relapse-free survival.