A candidate molecular signature associated with tamoxifen failure in primary breast cancer

Breast Cancer Research

Table 7 Univariate and multivariate analysis of the six genes in relation to OS among the 33 breast cancer samples from the independent cohort (Centre Léon Bérard, Lyon, France)

Genes	Univariate (n = 33)			Multivariate (n = 33)
	HR	95% CI	P ^a	HR	95% CI	P ^a
ESR1	0.09	0.02 to 0.38	<10^-4	0.17	0.03 to 0.86	0.032
FOS	0.12	0.03 to 0.42	<10^-4	0.22	0.06 to 1.00	0.049
BCL2	0.07	0.01 to 0.31	<10^-4			NS(2)^b
SNCG	0.24	0.08 to 0.75	0.008			NS(3)
IGFBP4	0.34	0.12 to 0.98	0.038			NS(1)
MET	1.08	0.40 to 2.88	NS	ND^c	ND	ND

^aP value was considered significant when P < 0.05. ^bNS(i), order in which the variable was deleted from the model. ^cND indicates 'not done'; multivariate analysis was done using the variables found to be significant in univariate analysis. CI, confidence interval; HR, hazard ratio; NS, not significant; OS, overall survival.

ISSN: 1465-542X