A candidate molecular signature associated with tamoxifen failure in primary breast cancer

Breast Cancer Research

Table 5 Statistical comparison of protein expression measured by TMA between the control and TF groups of tumor samples (n = 33; Ninewells Hospital, Dundee, UK)

Proteins	Quickscore	Samples (n [%])		P ^a
		Control	TF
ER-α	0 and <4	1 (6)	11 (65)	0.0004
	From 4 to <8	4 (25)	4 (24)
	From 8 to <12	5 (31)	2 (12)
	From 12 to 18	6 (38)	0 (0)
SNCG	0 and <4	0 (0)	0 (0)	0.02
	From 4 to <8	6 (38)	7 (41)
	From 8 to <12	1 (6)	7 (41)
	From 12 to 18	9 (56)	3 (18)
IGFBP4	0 and <4	5 (31)	8 (47)	0.03
	From 4 to <8	4 (25)	5 (29)
	From 8 to <12	1 (6)	4 (24)
	From 12 to 18	6 (38)	0 (0)
c-Fos	0 and <4	1 (6)	0 (0)	NS (0.08)
	From 4 to <8	7 (44)	2 (12)
	From 8 to <12	1 (6)	2 (12)
	From 12 to 18	7 (44)	13 (76)
c-Met	0 and <4	1 (6)	0 (0)	NS (0.29)
	From 4 to <8	1 (6)	4 (24)
	From 8 to <12	6 (38)	8 (47)
	From 12 to 18	8 (50)	5 (29)
Bcl2	0 and <4	5 (31)	7 (41)	NS (0.78)
	From 4 to <8	4 (25)	2 (12)
	From 8 to <12	1 (6)	2 (12)
	From 12 to 18	6 (38)	6 (35)

^aP value (Fisher exact test) was considered significant when P < 0.05. ER, estrogen receptor; IGFBP, insulin-like growth factor binding protein; NS, not significant; SNCG, γ-synuclein; TF, tamoxifen failure; TMA, tissue microarray.

ISSN: 1465-542X