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Table 3 Genes potentially implicated in DCIS progression functionally classified within the biological process category

From: Evidence that molecular changes in cells occur before morphological alterations during the progression of breast ductal carcinoma

Functional process

Downregulated genes in pure DCIS

Upregulated genes in pure DCIS

Cell adhesion and migration

-

AZGP1, C20orf23, C20orf42, CHST10, COL17A1, DGCR2, GPR98, ITGB2, KIF1A, LPXN, NEDD9, PCDH10, PCLKC, PLEKHC1, RGMB

Signal transduction

CORO1C, CXCL9, IGSF6, LOX, NCOA4, NMU, SKIL

ARHGAP19, ARHGAP9, C16orf5, C3AR1, CHRNB1, EPOR, FCGR2B, FCN1, FGFBP1, GIPC1, GPR77, KDR, MAPRE2, PIAS2, RHOU, STK25

Cell proliferation and apoptosis

NOX4, SULF1

ANAPC13, CDC45L, ERC1, IFT57, RARRES3, REC8L1, SHC1, UTP20

Transcriptional regulation

MED10, PHTF1

AOF2, ATF2, ETNK2, IRF8, MBD3, MGC21874, SMARCA3, SOX13, TARDBP, ZBTB5

Metabolism

P4HA1

B4GALT5, BCHE, CA3, CPNE3, CPT1A, DHRS12, FN3K, GBGT1, OSBPL7, PEPD, PITPNM2, UFD1L, ZFP36L1

Miscellaneous

CCT5, MARCH8, PTBP2, RAD51AP1

ALMS1, ARFIP1, BOP1, CAMP, CAV1, CIRBP, CLINT1, CLTCL1, CTSZ, DHX35, EYA2, FCGR3A, GOSR2, IMMT, INOC1, KBTBD10, KCTD15, KIAA0664, KPNA6, LSM4, MARK3, MRPS17, NGDN, NUP50, P4HB, PMPCA, POLD3, POMGNT1, PPP2R3A, RABEPK, RPL3, RPL41, RSL1D1, SAMD4A, SLC6A20, SLC9A5, SPOCK2, STX11, SV2B, SYN1, TBC1D9B, TRAP1, TXNDC11, TXNL2, UBXD1, VPS54

Unknown

C13orf23, C7orf24, HN1, KIAA1211, RUNDC1

ADFP, ANKRD6, BIN2, C10orf26, C13orf24, C1orf66, CTTNBP2NL, DENND3, FAM40B, ITPKC, KIAA0748, LETMD1, LRCH2, LTBP3, NCDN, PPM1H, PPTC7, RNF43

  1. Genes belonged to more than one biological process were assigned in a hierarchical manner in the following order: cell adhesion and migration; signal transduction; cell proliferation and apoptosis; transcriptional regulation; and metabolism. Those with no classification in the five categories were classified as miscellaneous. DCIS, ductal carcinoma in situ.