Figure 1

Hazard rate estimates for selected events in 1526 patients undergoing conservative surgery. Each point represents the measure of the hazard rate of the given event within a three-month interval. The smoothed curve was obtained by a Kernel-like smoothing procedure. (a) Hazard rate for any recurrence (including both local and distant disease relapses). (b) The hazard rate for recurrence is split into its components: local recurrence (red line) and distant metastasis (blue line). (c) Hazard rate for contralateral breast cancer. (d) Hazard rate for second primary cancer.