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Table 3 Distribution of 11q protein staining category in relation to CGH gene profile

From: Gene products of chromosome 11q and their association with CCND1gene amplification and tamoxifen resistance in premenopausal breast cancer

Protein expression

Gene expression

 
 

Deletion

Normal

Gain/Amp

Total

P valuea

Cortactin

    

0.664

   Low/intermediate expression

1

13

5

19

 

   Over-expression

0

6

3

9

 

   Total

1

19

8

28

 

FADD

    

0.477

   Low/intermediate expression

0

16

7

23

 

   Over-expression

0

3

3

6

 

   Total

0

19

10

29

 

Cyclin D1

    

0.083

   Low/intermediate expression

3

30

10

43

 

   Over-expression

0

1

3

4

 

   Total

3

31

13

47

 

Pak1

    

0.027

   Negative

3

28

4

35

 

   Positive

0

4

5

9

 

   Total

3

32

9

44

 

Chk1

    

0.241b

   0% to 5% (low)

2

6

0

8

 

   6% to 50% (intermediate)

5

18

0

23

 

   51% to 100% (high)

0

7

0

7

 

   Total

7

31

0

38

 
  1. aCorrelations were calculated using Mann-Whitney test (two-sided) unless otherwise specified. bSpearman's ρ. Amp, amplification; CGH, comparative genomic hybridization; Chk1, checkpoint kinase 1; FADD, Fas-associated death domain; Pak1, p21-activated kinase 1.