Gene products of chromosome 11q and their association with CCND1gene amplification and tamoxifen resistance in premenopausal breast cancer

Table 2 Distribution of Chk1 staining category according to clinico-pathological parameters

	Chk1 fraction positive nuclei (%)
Variable	0 to 5 (n = 108)	6 to 50 (n = 192)	51 to 100 (n = 41)	P value
Tumor type				0.001^a
Ductal	94	168	32
Lobular	10	3	2
Medullary	1	15	6
Missing cases: 169
Tumor size (mm)				0.012^b
≥20	48	64	10
>20	60	127	31
Missing cases: 160
Lymph node status				0.131^b
Negative	24	54	14
Positive	83	138	27
Missing cases: 160
NHG				<0.001^c
I	18	14	0
II	67	66	3
III	20	106	36
Missing cases: 170
Ki67 positive (%)				<0.001^c
0 to 10	70	55	2
11 to 25	19	61	5
26 to 100	10	52	32
Missing cases: 194

^aKruskal-Wallis test (two-sided). ^bMann-Whitney test (two-sided). ^cSpearman's ρ. Chk1, checkpoint kinase 1; NHG, Nottingham Histological Grade.

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