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Table 4 EGFR and HER2 expression in primary tumor and in CTCs

From: Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients

  Early disease Metastatic disease
  Primary tumor CTCs Primary tumor CTCs
Patient number HER2 EGFR HER2 EGFR HER2 EGFR HER2 EGFR
1 - + + + - - + -
2 +a NA + - + - + -
3 - - - + + NA + +
4 - - + - - - - -
5 - - + - - - + -
6 - NA + + - NA - -
7 - + - + + - + -
8 - - - - - - + -
9 + - - - - NA - -
10 + - + + + - + +
11 - + - - + NA - +
12 - - + - - + - -
13 - - + - - NA - +
14 - - - - - - + +
15 - NA - - - NA + +
16 NA NA - + - - + +
  1. aScore +3 or fluorescence in situ hybridization positive. CTC, circulating tumor cell; EGFR, epidermal growth factor receptor; HER, human epidermal growth factor receptor.
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