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Table 4 EGFR and HER2 expression in primary tumor and in CTCs

From: Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients

 

Early disease

Metastatic disease

 

Primary tumor

CTCs

Primary tumor

CTCs

Patient number

HER2

EGFR

HER2

EGFR

HER2

EGFR

HER2

EGFR

1

-

+

+

+

-

-

+

-

2

+a

NA

+

-

+

-

+

-

3

-

-

-

+

+

NA

+

+

4

-

-

+

-

-

-

-

-

5

-

-

+

-

-

-

+

-

6

-

NA

+

+

-

NA

-

-

7

-

+

-

+

+

-

+

-

8

-

-

-

-

-

-

+

-

9

+

-

-

-

-

NA

-

-

10

+

-

+

+

+

-

+

+

11

-

+

-

-

+

NA

-

+

12

-

-

+

-

-

+

-

-

13

-

-

+

-

-

NA

-

+

14

-

-

-

-

-

-

+

+

15

-

NA

-

-

-

NA

+

+

16

NA

NA

-

+

-

-

+

+

  1. aScore +3 or fluorescence in situ hybridization positive. CTC, circulating tumor cell; EGFR, epidermal growth factor receptor; HER, human epidermal growth factor receptor.
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