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Table 3 Number of EGFR, HER2, pPI3K, and pAkt-positive CTCs in breast cancer patients

From: Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients

Number of CTCs per sample EGFR HER2 pPI3K PAkt
  Early disease (n = 16) Metastatic disease (n = 16) Early disease (n = 16) Metastatic disease (n = 16) Early disease (n = 16) Metastatic disease (n = 16) Early disease (n = 16) Metastatic disease (n = 16)
1 2 (13) 1 (6) 5 (31) 6 (38) 6 (31) 3 (19) 5 (31) 4 (25)
2 4 (25) 1 (6) 1 (6) 2 (13) 5 (31) 2 (13) 4 (25) 3 (19)
3 - - - - - 4 (25) 1 (6) 2 (13)
4 - 2 (13) 1 (6) 1 (6) 2 (13)   2 (13) -
≥ 5 - 3 (19) 1 (6) 1 (6) 1 (6) 5 (31) 1 (6) 4 (25)
  1. Values are expressed as number (%). CTC, circulating tumor cell; EGFR, epidermal growth factor receptor; HER, human epidermal growth factor receptor; PI3K, phosphoinositide-3 kinase.
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