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Table 3 Number of EGFR, HER2, pPI3K, and pAkt-positive CTCs in breast cancer patients

From: Phosphorylated EGFR and PI3K/Akt signaling kinases are expressed in circulating tumor cells of breast cancer patients

Number of CTCs per sample

EGFR

HER2

pPI3K

PAkt

 

Early disease (n = 16)

Metastatic disease (n = 16)

Early disease (n = 16)

Metastatic disease (n = 16)

Early disease (n = 16)

Metastatic disease (n = 16)

Early disease (n = 16)

Metastatic disease (n = 16)

1

2 (13)

1 (6)

5 (31)

6 (38)

6 (31)

3 (19)

5 (31)

4 (25)

2

4 (25)

1 (6)

1 (6)

2 (13)

5 (31)

2 (13)

4 (25)

3 (19)

3

-

-

-

-

-

4 (25)

1 (6)

2 (13)

4

-

2 (13)

1 (6)

1 (6)

2 (13)

 

2 (13)

-

≥ 5

-

3 (19)

1 (6)

1 (6)

1 (6)

5 (31)

1 (6)

4 (25)

  1. Values are expressed as number (%). CTC, circulating tumor cell; EGFR, epidermal growth factor receptor; HER, human epidermal growth factor receptor; PI3K, phosphoinositide-3 kinase.