Table 4 Nonhematologic toxicity per schedule in patients aged ≥ 60 years, n (%)
Docetaxel | Paclitaxel | Total | |
|---|---|---|---|
Fatigue grade 1 to grade 4 | |||
Patients aged <60 years | 1,922 (88.4) | - | 1,922 (88.4) |
Patients aged 60 to 64 years | 362 (87.0) | - | 362 (87.0) |
Patients aged >64 years | 235 (90.4) | - | 235 (90.4) |
P value | 0.414 | - | 0.414 |
Fatigue grade 3 to grade 4 | |||
Patients aged <60 years | 315 (14.5) | - | 315 (14.5) |
Patients aged 60 to 64 years | 81 (19.5) | - | 81 (19.5) |
Patients aged >64 years | 61 (23.5) | - | 61 (23.5) |
P value | <0.001 | - | <0.001 |
Loss of appetite grade 1 to grade 3 | |||
Patients aged <60 years | 441 (67.0) | - | 441 (67.0) |
Patients aged 60 to 64 years | 110 (73.8) | - | 110 (73.8) |
Patients aged >64 years | 76 (84.4) | - | 76 (84.4) |
P value | 0.002 | - | 0.002 |
Loss of appetite grade 3 | |||
Patients aged <60 years | 76 (11.6) | - | 76 (11.6) |
Patients aged 60 to 64 years | 33 (22.1) | - | 33 (22.1) |
Patients aged >64 years | 18 (20.0) | - | 18 (20.0) |
P value | 0.001 | - | 0.001 |
Nausea/vomiting grade 1 to grade 4 | |||
Patients aged <60 years | 1,980 (77.5) | 473 (84.6) | 2,453 (78.8) |
Patients aged 60 to 64 years | 410 (79.3) | 101 (85.6) | 511 (80.5) |
Patients aged >64 years | 290 (85.5) | 62 (78.5) | 352 (84.2) |
P value | 0.003 | 0.337 | 0.028 |
Nausea/vomiting grade 3 to grade 4 | |||
Patients aged <60 years | 206 (8.1) | 32 (5.7) | 238 (7.6) |
Patients aged 60 to 64 years | 47 (9.1) | 2 (1.7) | 49 (7.7) |
Patients aged >64 years | 34 (10.0) | 0 (0.0) | 39 (9.3) |
P value | 0.392 | 0.175 | 0.479 |
Mucositis grade 1 to grade 4 | |||
Patients aged <60 years | 1,736 (68.0) | 299 (53.5) | 2,035 (65.4) |
Patients aged 60 to 64 years | 360 (69.9) | 77 (65.3) | 437 (69.0) |
Patients aged >64 years | 231 (68.5) | 42 (53.2) | 273 (65.6) |
P value | 0.688 | 0.060 | 0.205 |
Mucositis grade 3 to grade 4 | |||
Patients aged <60 years | 115 (4.5) | 9 (1.6) | 124 (4.0) |
Patients aged 60 to 64 years | 26 (5.0) | 7 (5.9) | 33 (5.2) |
Patients aged >64 years | 25 (7.4) | 5 (6.3) | 30 (7.2) |
P value | 0.064 | 0.004 | 0.007 |
Sensory neuropathy grade 1 to grade 4 | |||
Patients aged <60 years | 39 (1.5) | 15 (2.7) | 54 (1.7) |
Patients aged 60 to 64 years | 16 (3.1) | 2 (1.7) | 18 (2.8) |
Patients aged >64 years | 6 (1.8) | 3 (3.8) | 9 (2.2) |
P value | 0.729 | 0.803 | 0.647 |
Sensory neuropathy grade 3 to grade 4 | |||
Patients aged <60 years | 39 (1.5) | 15 (2.7) | 54 (1.7) |
Patients aged 60 to 64 years | 16 (3.1) | 2 (1.7) | 18 (2.8) |
Patients aged >64 years | 6 (1.8) | 3 (3.8) | 9 (2.2) |
P value | 0.050 | 0.662 | 0.177 |
Conjunctivitis grade 1 to grade 3 | |||
Patients aged <60 years | 1,002 (46.1) | - | 1,002 (46.1) |
Patients aged 60 to 64 years | 191 (45.9) | - | 191 (45.9) |
Patients aged >64 years | 119 (45.9) | - | 119 (45.9) |
P value | 0.996 | - | 0.996 |
Conjunctivitis grade 3 | |||
Patients aged <60 years | 25 (1.2) | - | 25 (1.2) |
Patients aged 60 to 64 years | 7 (1.7) | - | 7 (1.7) |
Patients aged >64 years | 4 (1.5) | - | 4 (1.5) |
P value | 0.615 | - | 0.615 |
Nail changes grade 1 to grade 3 | |||
Patients aged <60 years | 849 (39.1) | - | 849 (39.1) |
Patients aged 60 to 64 years | 171 (41.3) | - | 171 (41.3) |
Patients aged >64 years | 100 (38.8) | - | 100 (38.8) |
P value | 0.680 | - | 0.680 |
Nail changes grade 3 | |||
Patients aged <60 years | 22 (1.0) | - | 22 (1.0) |
Patients aged 60 to 64 years | 6 (1.4) | - | 6 (1.4) |
Patients aged >64 years | 1 (0.4) | - | 1 (0.4) |
P value | 0.411 | - | 0.411 |
Skin changes grade 1 to grade 4 | |||
Patients aged <60 years | 1,126 (44.1) | 202 (36.1) | 1,328 (42.7) |
Patients aged 60 to 64 years | 221 (42.9) | 51 (43.2) | 272 (43.0) |
Patients aged >64 years | 137 (40.8) | 25 (31.6) | 162 (39.0) |
P value | 0.479 | 0.212 | 0.348 |
Skin changes grade 3 to grade 4 | |||
Patients aged <60 years | 43 (1.7) | 4 (0.7) | 47 (1.5) |
Patients aged 60 to 64 years | 19 (3.7) | 2 (1.7) | 21 (3.3) |
Patients aged >64 years | 12 (3.6) | 0 (0.0) | 12 (2.9) |
P value | 0.003 | 0.388 | 0.003 |
Diarrhea grade 1 to grade 4 | |||
Patients aged <60 years | 1,037 (40.6) | 137 (24.5) | 1,174 (37.7) |
Patients aged 60 to 64 years | 219 (42.2) | 30 (25.4) | 249 (39.3) |
Patients aged >64 years | 171 (50.6) | 13 (16.5) | 184 (44.1) |
P value | 0.002 | 0.263 | 0.039 |
Diarrhea grades 3 to grade 4 | |||
Patients aged <60 years | 99 (3.9) | 7 (1.3) | 106 (3.4) |
Patients aged 60 to 64 years | 24 (4.7) | 0 (0.0) | 24 (3.8) |
Patients aged >64 years | 17 (5.0) | 0 (0.0) | 17 (4.1) |
P value | 0.482 | 0.288 | 0.731 |
Fluid retention grade 1 to grade 4 | |||
Patients aged <60 years | 954 (37.4) | - | 954 (37.4) |
Patients aged 60 to 64 years | 188 (36.5) | - | 188 (36.5) |
Patients aged >64 years | 128 (38.0) | - | 128 (38.0) |
P value | 0.898 | - | 0.898 |
Fluid retention grade 3 to grade 4 | |||
Patients aged <60 years | 42 (1.6) | - | 42 (1.6) |
Patients aged 60 to 64 years | 7 (1.4) | - | 7 (1.4) |
Patients aged >64 years | 4 (1.2) | - | 4 (1.2) |
P value | 0.754 | - | 0.754 |
Infection with neutropenia grade 1 to grade 4 | |||
Patients aged <60 years | 174 (16.7) | 36 (6.4) | 210 (13.1) |
Patients aged 60 to 64 years | 48 (19.4) | 15 (12.5) | 63 (17.2) |
Patients aged >64 years | 35 (21.0) | 3 (3.8) | 38 (15.4) |
P value | 0.305 | 0.029 | 0.104 |
Infection with neutropenia grade 3 to grade 4 | |||
Patients aged <60 years | 21 (2.0) | 4 (0.7) | 25 (1.6) |
Patients aged 60 to 64 years | 9 (3.6) | 3 (2.5) | 12 (3.3) |
Patients aged >64 years | 8 (4.8) | 2 (2.5) | 10 (4.1) |
P value | 0.062 | 0.129 | 0.010 |
Creatinine grade 1 to grade 4 | |||
Patients aged <60 years | 73 (3.4) | 7 (1.3) | 80 (3.0) |
Patients aged 60 to 64 years | 26 (6.3) | 5 (4.2) | 31 (5.8) |
Patients aged >64 years | 20 (7.8) | 5 (7.0) | 25 (7.6) |
P value | <0.001 | 0.003 | <0.001 |
Hot flushes grade 1 to grade 3 | |||
Patients aged <60 years | 425 (64.6) | - | 425 (64.6) |
Patients aged 60 to 64 years | 88 (59.1) | - | 88 (59.1) |
Patients aged >64 years | 46 (51.1) | - | 46 (51.1) |
P value | 0.031 | - | 0.031 |
Hot flushes grade 3 | |||
Patients aged <60 years | 66 (10.0) | - | 66 (10.0) |
Patients aged 60 to 64 years | 15 (10.1) | - | 15 (10.1) |
Patients aged >64 years | 2 (2.2) | - | 2 (2.2) |
P value | 0.053 | - | 0.053 |
Liver enzymes grade 1 to grade 4 | |||
Patients aged <60 years | 1,198 (47.2) | 447 (82.8) | 1,645 (53.5) |
Patients aged 60 to 64 years | 193 (42.0) | 95 (84.1) | 288 (50.3) |
Patients aged >64 years | 111 (35.7) | 53 (74.6) | 164 (42.9) |
P value | <0.001 | 0.206 | <0.001 |
Liver enzymes grade 3 to grade 4 | |||
Patients aged <60 years | 48(1.9) | 65 (12.0) | 113 (3.7) |
Patients aged 60 to 64 years | 12 (2.6) | 10 (8.8) | 22 (3.8) |
Patients aged >64 years | 7 (2.3) | 0 (0.0) | 7 (1.8) |
P value | 0.574 | 0.006 | 0.166 |