Table 1 Subtype specificity of RB1 LOH and RB1 and p16INK4a immunohistochemistry
| Â | Basal-like | HER2-enriched | Luminal A | Luminal B | Normal-like | Total | Â |
|---|---|---|---|---|---|---|---|
RB1 LOH | Â | Â | Â | Â | Â | Â | Â |
LOH positive | 13 (48.2) | 3 (11.1) | 3 (11.1) | 8 (29.6) | 0 (0) | 27 | Â |
LOH negative | 5 (12.5) | 6 (15.0) | 17 (42.5) | 5 (12.5) | 7 (17.5) | 40 | Â |
Total | 18 | 9 | 20 | 13 | 7 | 67 | p = 2.26E-04 |
RB IHC | Â | Â | Â | Â | Â | Â | Â |
0 | 6 (42.9) | 2 (14.3) | 3 (21.4) | 3 (21.4) | 0 (0) | 14 | Â |
1+ | 13 (29.6) | 5 (11.4) | 14 (31.8) | 4 (9.1) | 8 (18.2) | 44 | Â |
2+ | 5 (12.8) | 6 (15.4) | 14 (35.9) | 6 (15.4) | 8 (20.5) | 39 | Â |
3+ | 7 (35.0) | 2 (10.0) | 4 (20.0) | 7 (35.0) | 0 (0) | 20 | Â |
Total | 31 | 15 | 35 | 20 | 16 | 117 | p = 0.0644 |
p16 IHC | Â | Â | Â | Â | Â | Â | Â |
0 | 2 (8.0) | 4 (16.0) | 8 (32.0) | 6 (24.0) | 5 (20.0) | 25 | Â |
1+ | 5 (15.2) | 3 (9.1) | 15 (45.5) | 5 (15.2) | 5 (15.2) | 33 | Â |
2+ | 4 (13.8) | 4 (13.8) | 9 (31.0) | 6 (20.7) | 6 (20.7) | 29 | Â |
3+ | 22 (68.8) | 4 (12.5) | 3 (9.4) | 3 (9.4) | 0 (0) | 32 | Â |
Total | 33 | 15 | 35 | 20 | 16 | 119 | p = 1.41E-05 |