A divergent role for estrogen receptor-beta in node-positive and node-negative breast cancer classified according to molecular subtypes: an observational prospective study

Table 2 Multivariate analyses of negative prognostic factors for disease-free survival

	Disease-free survival
Factors	HR (95% CI)	P value
All patients (728)
pT stage (3–4 versus 1–2)	2.51 (1.40–4.50)	0.002
pN stage (positive versus negative)	2.44 (1.62–3.66)	<0.0001
Ki67 (positive versus negative)	1.59 (1.08–2.34)	0.02
Node-positive patients (278)
pT stage (3–4 versus 1–2)	2.51 (1.40–4.50)	0.002
ER-β (positive versus negative)	1.55 (1.93–2.57)	0.09
Node-negative patients (450)
ER-β (negative versus positive)	1.76 (0.95–3.24)	0.07
Ki67 (positive versus negative)	2.16 (1.15–4.04)	0.02

Cox regression analysis using a forward stepwise procedure (enter limit = 0.10, remove limit = 0.15). CI, confidence interval; ER-β, estrogen receptor-beta; HR, hazard ratio; pN, pathological node status; pT, pathological tumor size.

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