Figure 1

Heatmaps of seven-gene immune response-modules. Heatmaps of gene expression of the seven-gene immune response-module for the training and six test cohorts (red = high relative expression, green = low). Samples are clustered into two groups according to the partitioning around medoids algorithm [28] (purple = group overexpressing the immune response-module, yellow = group underexpressing the immune response-module). Clinical outcome as defined by a disease-specific death event (or distant metastasis if the former is not available) is also shown (black = poor, grey = good, white = missing data). Note that in some cases not all seven genes could be mapped to the external platform. C1QA = complement component 1, q subcomponent, A chain; HLA-F = major histocompatibility complex, class I, F; IGLC2 = immunoglobulin lambda constant 2; LY9 = lymphocyte antigen 9; TNFRSF17 = tumour necrosis factor receptor superfamily member 17; SPP1 = secreted phosphoprotein 1 (osteopontin); XCL2 = chemokine (C motif) ligand 2.