TY - JOUR AU - Neven, Patrick AU - Van Gorp, Toon AU - Deraedt, Karen PY - 2008 DA - 2008/09/04 TI - A gene signature of loss of oestrogen receptor (ER) function and oxidative stress links ER-positive breast tumours with an absent progesterone receptor and a poor prognosis JO - Breast Cancer Research SP - 109 VL - 10 IS - 5 AB - Prognostic gene signatures like the wound and hypoxia signature differ by assumptions of cellular growth. Although gene signatures show little overlap, they also track within the group of luminal breast tumours those with a high proliferation and poor prognosis. Oxidative stress is another assumption of cellular growth. It affects several pathological conditions through its influence on the regulation of protein kinases and signal transduction pathways. A comprehensive set of 62 core genes from cultured oestrogen- and oestrogen receptor-deprived epithelial breast cancer cells is responsive to three forms of oxidative stress. Evidence is presented that oxidative stress involves the development of an aggressive subset of primary oestrogen receptor-positive breast tumours. SN - 1465-542X UR - https://doi.org/10.1186/bcr2135 DO - 10.1186/bcr2135 ID - Neven2008 ER -