TY - JOUR AU - Howell, Sacha J. AU - Anderson, Elizabeth AU - Hunter, Tom AU - Farnie, Gillian AU - Clarke, Robert B. PY - 2008 DA - 2008/08/05 TI - Prolactin receptor antagonism reduces the clonogenic capacity of breast cancer cells and potentiates doxorubicin and paclitaxel cytotoxicity JO - Breast Cancer Research SP - R68 VL - 10 IS - 4 AB - Exogenous prolactin is mitogenic and antiapoptotic in breast cancer cells, and overexpression of autocrine prolactin cDNA in breast cancer cell lines has been shown to stimulate their growth and to protect against chemotherapy-induced apoptosis. We examined the effects of the 'pure' prolactin receptor antagonist Δ1–9-G129R-hPrl (Δ1–9) on the breast cancer cell number and clonogenicity, alone and in combination with chemotherapy. SN - 1465-542X UR - https://doi.org/10.1186/bcr2129 DO - 10.1186/bcr2129 ID - Howell2008 ER -