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Table 5 Frequency of molecular phenotypes among DCIS and invasive breast cancers according to tumour gradea, Nurses' Health Study (1976 to 1996)

From: Comparison of molecular phenotypes of ductal carcinoma in situand invasive breast cancer

Tumour type Luminal A Luminal B Her2 type Basal Unclassified
DCIS      
DCIS, low nuclear grade 26 (92.9) 1 (3.6) 0 1 (3.6) 0
DCIS, intermediate grade 109 (79.0) 15 (10.9) 6 (4.4) 6 (4.4) 2 (1.5)
DCIS, high nuclear grade 35 (33.0) 20 (18.9) 31 (29.3) 14 (13.2) 6 (5.7)
Invasive tumours      
Well-differentiated 134 (95.7) 2 (1.4) 0 2 (1.4) 2 (1.4)
Moderately differentiated 344 (79.3) 24 (5.5) 21 (4.8) 31 (7.1) 14 (3.2)
Poorly differentiated 252 (56.8) 20 (4.5) 43 (9.7) 99 (22.3) 30(6.8)
  1. aGrade of DCIS and invasive tumours as determined by centralised pathology review. DCIS, ductal carcinoma in situ.