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Table 2 Mean percentage of mammographic density (MD) according to breast cancer susceptibility loci, Nurses' Health Study controls (1989 to 1998)

From: Breast cancer susceptibility loci and mammographic density

   N Mean %MDa Mean %MDb
rs2981582 G/G 421 26.9 26.7
  G/A 539 26.9 26.6
  A/A 160 26.8 28.0
p value d    0.56 0.98
rs12443621 A/A 298 25.0 25.7
  A/G 561 27.3 26.9
  G/G 267 27.4 27.1
p value d    0.12 0.25
rs13281615 A/A 377 27.6 27.2
  A/G 553 25.9 26.3
  G/G 198 28.1 27.5
p value d    0.90 0.91
rs3817198 A/A 489 26.0 25.9
  A/G 491 27.8 27.8
  G/G 119 25.9 26.1
p value d    0.95 0.79
rs889312 T/T 622 28.3 28.2
  T/G 428 24.7 25.1
  G/G 76 28.6 27.3
p value d    0.12 0.06
rs4666451 G/G 405 26.9 27.4
  A/G 531 27.2 26.7
  A/A 184 25.7 25.8
p value d    0.43 0.13
rs2107425 G/G 572 27.5 27.5
  G/A 440 25.8 25.8
  A/A 108 26.7 26.3
p value d    0.39 0.24
rs981782 A/A 336 27.9 27.0
  A/C 544 26.5 26.9
  C/C 231 26.7 26.8
p value d    0.15 0.40
rs8051542 G/G 307 26.8 26.8
  G/A 383 25.7 25.6
  A/A 173 29.3 29.2
p value d    0.67 0.64
rs30099 C/C 929 26.9 27.0
  C/T 193 26.0 25.5
  T/T 8 28.0 24.0
p value d    0.81 0.28
rs3803662 G/G 590 26.2 26.4
  G/A 434 27.5 26.9
  A/A 90 27.1 28.6
p value d    0.53 0.37
  1. aAge adjusted.
  2. bMultivariate adjusted for the following: age (continuous), body mass index (BMI) (continuous), alcohol consumption (none, <5 g/day, 5 to 14.9 g/day, 15+ g/day), age at first birth/parity (nulliparous, age at first birth <25, age at first birth 25 to 29, age at first birth >30), history of benign breast disease (yes/no), family history of breast cancer (yes/no).
  3. cMultivariate adjusted for the following: age, BMI, alcohol consumption, age at first birth/parity, history of benign breast disease, family history of breast cancer, postmenopausal status/hormone use (premenopausal, never user, current user, past user).
  4. dp value based on genotype coded as ordinal variable regressed on square root transformed MD.