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Table 2 Mean percentage of mammographic density (MD) according to breast cancer susceptibility loci, Nurses' Health Study controls (1989 to 1998)

From: Breast cancer susceptibility loci and mammographic density

  

N

Mean %MDa

Mean %MDb

rs2981582

G/G

421

26.9

26.7

 

G/A

539

26.9

26.6

 

A/A

160

26.8

28.0

p value d

  

0.56

0.98

rs12443621

A/A

298

25.0

25.7

 

A/G

561

27.3

26.9

 

G/G

267

27.4

27.1

p value d

  

0.12

0.25

rs13281615

A/A

377

27.6

27.2

 

A/G

553

25.9

26.3

 

G/G

198

28.1

27.5

p value d

  

0.90

0.91

rs3817198

A/A

489

26.0

25.9

 

A/G

491

27.8

27.8

 

G/G

119

25.9

26.1

p value d

  

0.95

0.79

rs889312

T/T

622

28.3

28.2

 

T/G

428

24.7

25.1

 

G/G

76

28.6

27.3

p value d

  

0.12

0.06

rs4666451

G/G

405

26.9

27.4

 

A/G

531

27.2

26.7

 

A/A

184

25.7

25.8

p value d

  

0.43

0.13

rs2107425

G/G

572

27.5

27.5

 

G/A

440

25.8

25.8

 

A/A

108

26.7

26.3

p value d

  

0.39

0.24

rs981782

A/A

336

27.9

27.0

 

A/C

544

26.5

26.9

 

C/C

231

26.7

26.8

p value d

  

0.15

0.40

rs8051542

G/G

307

26.8

26.8

 

G/A

383

25.7

25.6

 

A/A

173

29.3

29.2

p value d

  

0.67

0.64

rs30099

C/C

929

26.9

27.0

 

C/T

193

26.0

25.5

 

T/T

8

28.0

24.0

p value d

  

0.81

0.28

rs3803662

G/G

590

26.2

26.4

 

G/A

434

27.5

26.9

 

A/A

90

27.1

28.6

p value d

  

0.53

0.37

  1. aAge adjusted.
  2. bMultivariate adjusted for the following: age (continuous), body mass index (BMI) (continuous), alcohol consumption (none, <5 g/day, 5 to 14.9 g/day, 15+ g/day), age at first birth/parity (nulliparous, age at first birth <25, age at first birth 25 to 29, age at first birth >30), history of benign breast disease (yes/no), family history of breast cancer (yes/no).
  3. cMultivariate adjusted for the following: age, BMI, alcohol consumption, age at first birth/parity, history of benign breast disease, family history of breast cancer, postmenopausal status/hormone use (premenopausal, never user, current user, past user).
  4. dp value based on genotype coded as ordinal variable regressed on square root transformed MD.