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Table 1 Shared genetic and genomic features between mouse models of mammary cancer and human breast tumor subtypes

From: Unlocking the power of cross-species genomic analyses: identification of evolutionarily conserved breast cancer networks and validation of preclinical models

Mouse model Shared features Reference Mouse genomic changes Reference
Luminal     
   p53fp/fp, WAP-Cre ER+ A.M. Michalowska, unpublished data   
   MMTV-Neu ER-, K8/K18+, and XBP1+ [7]   
   MMTV-PyMT ER-, K8/K18+, XBP1+, and GATA3+ [7]   
   WAP-Myc ER-, K8/K18+, XBP1+, and GATA3+ [7]   
   WAP-Int3 ER-, K8/K18+, and GATA3+ [7]   
Basal-like     
   C3(1)Tag ER-, Her2-, kRAS2 amplification, K5+, proliferation signature, and poor outcome [6, 7] Chromosome 6 [21]
   Brca1+/-, p53+/-, IR K5+ [7]   
   WAP-Tag Proliferation signature [7]   
  Proliferation signature [7]   
   WAP-T121     
   Brca1co/co, MMTV-Cre, p53+/- K5+ [7] Chromosomes 4, 11, 14, 15, and X [29]
   DMBA-induced adenocarcinoma K5+ [7]   
Her2/Neu     
   Conditional expression of endogenous Neu and promoter driven-activated Neu ErbB2 amplification [32] Chromosomes 4 and 11 [32, 33]
Normal breast     
   MMTV-Wnt1 K5+ [7]   
Claudin-low     
   Tumors with spindle cell morphology, including Brca1co/co, MMTV-Cre, p53+/-, DMBA-induced spindle, and p53 null transplant Low expression: claudins 3, 4, and 7, occlucdin, and e-cadherin [7]   
  1. ER, estrogen receptor.