Unlocking the power of cross-species genomic analyses: identification of evolutionarily conserved breast cancer networks and validation of preclinical models

Table 1 Shared genetic and genomic features between mouse models of mammary cancer and human breast tumor subtypes

Mouse model	Shared features	Reference	Mouse genomic changes	Reference
Luminal
p53^fp/fp, WAP-Cre	ER⁺	A.M. Michalowska, unpublished data
MMTV-Neu	ER^-, K8/K18⁺, and XBP1⁺	[7]
MMTV-PyMT	ER^-, K8/K18⁺, XBP1⁺, and GATA3⁺	[7]
WAP-Myc	ER^-, K8/K18⁺, XBP1⁺, and GATA3⁺	[7]
WAP-Int3	ER^-, K8/K18⁺, and GATA3⁺	[7]
Basal-like
C3(1)Tag	ER^-, Her2^-, kRAS2 amplification, K5⁺, proliferation signature, and poor outcome	[6, 7]	Chromosome 6	[21]
Brca1^+/-, p53^+/-, IR	K5⁺	[7]
WAP-Tag	Proliferation signature	[7]
	Proliferation signature	[7]
WAP-T₁₂₁
Brca1^co/co, MMTV-Cre, p53^+/-	K5⁺	[7]	Chromosomes 4, 11, 14, 15, and X	[29]
DMBA-induced adenocarcinoma	K5⁺	[7]
Her2/Neu
Conditional expression of endogenous Neu and promoter driven-activated Neu	ErbB2 amplification	[32]	Chromosomes 4 and 11	[32, 33]
Normal breast
MMTV-Wnt1	K5⁺	[7]
Claudin-low
Tumors with spindle cell morphology, including Brca1^co/co, MMTV-Cre, p53^+/-, DMBA-induced spindle, and p53 null transplant	Low expression: claudins 3, 4, and 7, occlucdin, and e-cadherin	[7]

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