Signature comparison. The prognostic performance of the signatures is compared by the forest plots of hazard ratio and plotted as vertical color bars for comparison. Most signatures show similar performance. Prognostic performance for distant relapse-free survival (DRFS) of the signatures using partial signatures containing only proliferation genes in the untreated (a) and treated (c) populations. The performance of most signatures is not degraded; in fact, it is improved for p53-32. Prognostic performance for DRFS of the signatures using partial signatures containing nonproliferation genes in the untreated (b) and treated (d) populations.