Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer

Table 3 The association of response to preoperative CAF treatment and patients' clinical and pathological characteristics with expression levels of Skp2 and p27^Kip1

Characteristics	Response		P value
	+	-
Age (years)
>50	8	17	0.13
<50	9	6	0
Tumor grade
G1 + G2	16	8
G3	4	12	0.010*
Primary tumor
T2	5	2	0.151
T3	7	13
T4	8	5
Lymph node status
Positive	16	9	0.022*
Negative	4	11
Stage
IIA	3	1	0.289
IIB	2	6
IIIA	7	8
IIIB	8	5
Estrogen receptor status
Positive	15	9	0.053
Negative	5	11
Progesterone receptor status
Positive	14	8	0.057
Negative	6	12
HER-2 receptor status
Positive	6	3	0.212
Negative	14	17
p27^Kip1
High	19	16	0.037*
Low	1	4
Skp2
High	1	16	0.0001*
Low	19	4

*P value < 0.05 was considered statistically significant. +, ≥ 50% reduction in tumor size; -, no response or <50% reduction in tumor size; KIP, kinase inhibitor protein; Skp2, S-phase kinase protein 2.

ISSN: 1465-542X