Over-expression of Skp2 is associated with resistance to preoperative doxorubicin-based chemotherapy in primary breast cancer

Table 2 Expression of Skp2 and p27^Kip1 in relation to the clinical and pathological characteristics of patients

Characeristic	Skp-2			p27^kip1
	High	Low	P value	High	Low	P value
Age (years)
>50	8	17	0.083	20	5	0.591
<50	9	16		13	2
Tumor grade
G1	3	0	0.001	3	0	0.162
G2	4	19		20	2
G3	13	3		11	5
Primary tumor
T2	1	6	0.063	7	0	0.105
T3	12	8		14	6
T4	4	9		12	1
Lymph node status
Positive	8	17	0.083	21	4	0.747
Negative	9	6		12	3
Stage
IIA	1	3	0.449	4	0	0.407
IIB	5	3		6	2
IIIA	7	8		11	4
IIIB	4	9		12	1
Estrogen receptor status
Positive	6	18	0.006	24	0	0.001
Negative	11	5		9	7
Progesterone receptor status
Positive	5	17	0.005	21	1	0.017
Negative	12	6		12	6
Her2 receptor status
Positive	6	3	0.088	3	5	0.002
Negative	11	20		30	2

P values relate to the differences between protein expression and the variables. P value < 0.05 was considered statistically significant. T, tumor size (according to the American Joint Committee on Cancer TNM staging system). KIP, kinase inhibitor protein; Skp2, S-phase kinase protein 2.

ISSN: 1465-542X