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Table 3 Gene lists identified from the canonical pathway analyses shown in Figure 3b

From: Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays

Canonical pathway Hypermethylated Hypomethylated
ERK/MAPK signaling ARAF, CREB3, CREB5, DUSP4, EGFR, ELF3, FGFR3, FGFR4, FYN, HSPB2, LTK, MERTK, MKNK1, MYCN, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPM1J, PPP1CB, PPP1R10, PPP1R11, PPP1R14A, PPP2R1B, PRKACG, PRKAG2, PRKAR1A, PRKCG, RAC1, RAC2, RAPGEF1, RAPGEF4, ROR2, RPS6KA5, SHC1 ATF4, ELK1, ESR1, FOS, MAPKAPK5, MRAS, MYC, PIK3CA, PLA2G2A, PLA2G6, PPP1R3D, PPP1R7, PRKACA, PRKCD, STAT1
Axonal guidance signaling ADAM2, ADAM30, ARHGEF12, BAIAP2, BDNF, BMP6, BMP8A, BMP8B, CFL2, DPYSL5, EFNB3, EGFR, EPHA10, EPHA8, EPHB1, FGFR3, FGFR4, FYN, GLI1, GLI2, GNAL, GNAO1, GNAT2, GNG3, L1CAM, LTK, MAG, MERTK, MICAL1, MKNK1, MYL5, MYL7, NFATC1, NFATC4, NGFB, NTF5, PIK3R2, PIK ABLIM1, ADAM9, BMP15, CDC42, EPHA3, EPHB4, GNAS, KALRN, MRAS, MYL3, NFATC2, NTF3, NTN2L, PIK3CA, PRKACA, PRKCD, ROBO1, SMO, SRGAP3, WASL, WNT16, WNT2
B-cell receptor signaling BCL10, BCL2A1, BCL3, CALM3, CAMK2B, CARD10, CREB3, CREB5, GSK3A, INPP5D, LYN, MAP2K4, MAP3K11, MAPK13, NFATC1, NFATC4, NFKBIE, PIK3R2, PIK3R3, PIK3R5, PLCG2, POU2F2, PRKCQ, PTEN, RAC1, RAC2, RELA, SHC1 ATF4, BCL6, CDC42, CHUK, ELK1, FCGR2A, FCGR2B, FCGR2C, MAP2K7, MRAS, NFATC2, PIK3CA
Integrin signaling ACTA1, ACTB, ACTG2, ACTN3, ACTN4, BCAR3, CAPN5, CAPN9, CAPNS1, EGFR, FGFR3, FGFR4, FYN, ITGAX, LTK, MAP2K4, MAP3K11, MERTK, MRCL3, MRLC2, MYL5, MYL7, PIK3R2, PIK3R3, PIK3R5, PLCG2, PPP1CB, PTEN, RAC1, RAC2, RALA, RAPGEF1, RHOC, RHOT2, ROR2, SHC1, TLN1, TN ARF5, CAV1, CDC42, DDEF1, ITGA10, ITGB2, MRAS, MYLK, PIK3CA, TSPAN3, WASL
Huntington's disease signaling BDNF, BET1L, CACNA1B, CAPN5, CAPN9, CAPNS1, CREB3, CREB5, DNM3, EGFR, GNG3, HAP1, HSPA1A, HSPA1B, HSPA2, HSPA8, IGF1R, MAP2K4, MAPK13, NAPA, NAPG, NCOR2, NGFB, PACSIN1, PIK3R2, PIK3R3, PIK3R5, POLR2C, POLR2D, POLR2H, POLR2J, PRKCG, PRKCH, PRKCQ, SHC1, SNA ATF4, CASP2, CASP4, DLG4, DNAJC5, EP300, HDAC7A, MAP2K7, MAPK6, PIK3CA, PRKCD, SDHA, SDHB, STX16, VAMP3, YKT6