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Table 1 Top 20 putative hypermethylated gene targets detected by promoter analyses of 468GFP and 468LN cells

From: Epigenetic mapping and functional analysis in a breast cancer metastasis model using whole-genome promoter tiling microarrays

Gene name Common name Chromosome Fold change
FK506 binding protein 9, 63 kDa FKBP9 7p11.1 6.02
EGFR-coamplified and overexpressed protein ECOP 7p11.2 5.89
Hypothetical protein MGC33530 MGC33530 7p11.2 5.07
LanC lantibiotic synthetase component C-like 2 LANCL2 7p11.2 4.72
Coiled-coil-helix–coiled-coil–helix domain containing 2 CHCHD2 7p11.2 4.55
Epidermal growth factor receptor EGFR 7p11.2 4.54
FK506 binding protein 9, 63 kDa FKBP9 7p11.2 3.99
Immunoglobulin heavy locus IGH@ 14q32.33 3.89
ATPase, H+, lysosomal 42 kDa, V1 subunit C1 ATP6V1C1 8q22.3 3.86
Beta 1,3-galactosaminyltransferase, polypeptide 1 B3GALNT1 3q25 3.45
Sec61 gamma subunit SEC61G 7p11.2 3.45
Kelch-like 26 (Drosophila) KLHL26 19p13.11 3.44
phospholipase C, gamma 2 PLCG2 16q24.1 3.41
Ubiquitin specific peptidase 49 USP49 6p21 3.20
Solute carrier family 22, member 6 SLC22A6 11q13.1 3.07
Similar to metallo-beta-lactamase superfamily protein LOC153364 5q14.3 3.05
Src homology 2 domain containing adaptor protein B SHB 9p12 3.05
Cholinergic receptor, nicotinic, delta CHRND 2q33 2.92
Down syndrome critical region gene 9 DSCR9 21q21.13 2.83
Membrane associated ring protein 8 C3HC4 10q11.21 2.75
  1. The names and descriptions of the genes are given, as well as the fold change in hypermethylation in MDA-MB-468GFP-LN (468LN) cells relative to MDA-MB-468GFP (468GFP) cells.